Evidence map›Paper›PMID 41258544›Full record

ArticleScientific reports2025

Antibacterial activity and metabolomic profile of Zanthoxylum caribaeum Lam. aqueous extract against multidrug-resistant Staphylococcus aureus.

A Sellin, A I Adou, Y Duchaudé, S Schmidt, M Sylvestre, A P de la Mata, S L Nam, J Harynuk, G Cebrián-Torrejòn, S Ferdinand

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

A SellinUnit of Health and Environment, Institut Pasteur de Guadeloupe, Les Abymes, Guadeloupe, France.
A I AdouCOVACHIM-M2E laboratory, Department of Chemistry, Université des Antilles, BP 250, 97157, Pointe à Pitre Cedex, Guadeloupe, France.
Y DuchaudéCOVACHIM-M2E laboratory, Department of Chemistry, Université des Antilles, BP 250, 97157, Pointe à Pitre Cedex, Guadeloupe, France.
S SchmidtThe Metabolomics Innovation Centre (TMIC), Department of Chemistry, University of Alberta, Edmonton, AB, Canada.
M SylvestreCOVACHIM-M2E laboratory, Department of Chemistry, Université des Antilles, BP 250, 97157, Pointe à Pitre Cedex, Guadeloupe, France.
A P de la MataThe Metabolomics Innovation Centre (TMIC), Department of Chemistry, University of Alberta, Edmonton, AB, Canada.
S L NamThe Metabolomics Innovation Centre (TMIC), Department of Chemistry, University of Alberta, Edmonton, AB, Canada.
J HarynukThe Metabolomics Innovation Centre (TMIC), Department of Chemistry, University of Alberta, Edmonton, AB, Canada.
G Cebrián-TorrejònCOVACHIM-M2E laboratory, Department of Chemistry, Université des Antilles, BP 250, 97157, Pointe à Pitre Cedex, Guadeloupe, France.
S FerdinandUnit of Health and Environment, Institut Pasteur de Guadeloupe, Les Abymes, Guadeloupe, France. sferdinand@pasteur-guadeloupe.fr.

Funding

This work was supported by the Interreg Caraïbes program under the research project CARIBPHLORE n°8783
6 · The paper itself

Abstract

Improved antimicrobial medication or treatments are solutions that need to be combined to limit the impact of antibiotic resistance. Plants have historically been the source of many effective medicines. Zanthoxylum caribaeum is typically found in tropical regions and known for its wide range of plant metabolites that can be attributed to antibacterial activity. The aim of this study was to identify the metabolites potentially involved in the antibacterial activity of Z. caribaeum against resistant bacteria. The antibacterial effect of dried microwave-treated aqueous extracts of Z. caribaeum was tested in vitro against Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Enterococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa. Determination of the minimum inhibitory concentration (MIC) confirmed the inhibitory effect observed by the disc method. This showed that Z. caribaeum had a more pronounced effect on methicillin-resistant S. aureus (MRSA) at a high concentration with a MIC value of 1.6 × 10

Indexed as

Anti-Bacterial AgentsDrug Resistance, Multiple, BacterialMethicillin-Resistant Staphylococcus aureusPlant ExtractsZanthoxylumAcinetobacter baumanniiMetabolomicsMicrobial Sensitivity TestsAnti-Bacterial AgentsPlant ExtractsAntibacterial activityAqueous extractsMetabolomicsMultidrug resistant pathogensPhytochemistryZanthoxylum caribaeum

Identifiers

PMID41258544
PMCPMC12630891

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.