Evidence map›Paper›PMID 41258521›Full record

ArticleDiscover oncology2025

The impact of immune cells on the risk of breast cancer: a Mendelian randomization study.

Nana Zhang, Hao Wang, Zhenfeng Huang, Zibo Shen, Peng Zhang, Guoqiang Zhang

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PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Nana ZhangDepartment of Colorectal Oncology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Hao WangDepartment of Breast Surgery, Harbin Medical University cancer hospital, Harbin , Heilongjiang Province, China.
Zhenfeng HuangDepartment of Breast Surgery, Harbin Medical University cancer hospital, Harbin , Heilongjiang Province, China.
Zibo ShenBiomedical and life science faculty, King's College London, London, UK.
Peng ZhangFaculty of Economics and Management, Baotou Normal College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, China.
Guoqiang ZhangDepartment of Breast Surgery, Harbin Medical University cancer hospital, Harbin , Heilongjiang Province, China. zhangguoqiang@hrbmu.edu.cn.

Funding

Hai Yan Science Foundation of Harbin Medical University Cancer Hospital JJZD2019-05Hei Longjiang Postdoctoral Foundation LBH-Z16120
6 · The paper itself

Abstract

backgroundThe immune system is closely linked to the prognosis of breast cancer (BC). However, it remains unclear whether changes in immune cells contribute to the etiology of BC.

methodsGenetic variants associated with immune cells and BC and its subtypes were extracted from summary data of genome-wide association studies (GWAS) to explore the risk effects of immune cells on BC. Multivariable mendelian randomization (MVMR) was used to assess the independent risk effects of significantly associated immune traits.

resultsAfter correction in MVMR, granulocyte count (OR = 0.900, 95%CI:0.840-0.963) significantly decreased the risk of ER + BC; CD38 B cells (OR = 1.276, 95%CI:1.086-1.500) significantly increased the risk of ER- BC; granulocyte count (OR = 0.905, 95%CI:0.828-0.989) significantly decreased the risk of ER- BC; CD19 B cells (OR = 0.945, 95%CI:0.913-0.978) significantly decreased the risk of triple-negative breast cancer; CD11c dendritic cells (OR = 1.109, 95%CI:1.024-1.200) significantly decreased the risk of her 2 + BC. Additionally, there were observed interactions between CD19 and CD25 B cells, as well as granulocytes and CD4/naive CD4 T cells.

conclusionThe current MR study underscores the significant role of immune cells in the pathogenesis of BC, revealing complex interactions among immune subtypes.

Indexed as

Breast cancerImmune cellsMediation analysisMendelian randomizationMultivariable

Identifiers

PMID41258521
PMCPMC12623531

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