Evidence map›Paper›PMID 41258510›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Risk factors associated with the co-occurrence of severe pain and sleep disturbance in oncology outpatients receiving chemotherapy.

Aean Peattie, Sueann Mark, Astrid Block, Bruce A Cooper, Steven M Paul, Marilyn J Hammer, Frances Cartwright, Yvette P Conley, Jon D Levine, Christine Miaskowski

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Judicious use of latent profile analysis in supportive care: the distinction between mono- and multi-construct applications.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aean PeattieSchool of Nursing, University of California, 490 Illinois Street, Floor 12, San Francisco, CA, 94143-0610, USA.
Sueann MarkSchool of Nursing, University of California, 490 Illinois Street, Floor 12, San Francisco, CA, 94143-0610, USA.
Astrid BlockSchool of Nursing, University of California, 490 Illinois Street, Floor 12, San Francisco, CA, 94143-0610, USA.
Bruce A CooperSchool of Nursing, University of California, 490 Illinois Street, Floor 12, San Francisco, CA, 94143-0610, USA.
Steven M PaulSchool of Nursing, University of California, 490 Illinois Street, Floor 12, San Francisco, CA, 94143-0610, USA.
Marilyn J HammerPhyllis F. Cantor Center, Dana Farber Cancer Institute, Boston, MA, USA.
Frances CartwrightMount Sinai Medical Center, New York, NY, USA.
Yvette P ConleySchool of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.
Jon D LevineSchool of Medicine, University of California, San Francisco, CA, USA.
Christine MiaskowskiSchool of Nursing, University of California, 490 Illinois Street, Floor 12, San Francisco, CA, 94143-0610, USA. chris.miaskowski@ucsf.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeStudy purposes were to identify subgroups of patients with distinct co-occurring pain AND sleep disturbance profiles and evaluate for differences in demographic, clinical, pain, and sleep characteristics between the subgroups.

methodsOncology outpatients receiving chemotherapy (n = 972) completed self-report questionnaires on various demographic and clinical characteristics. Pain and sleep disturbance were assessed six times over two cycles of chemotherapy, using the Brief Pain Inventory and the General Sleep Disturbance Scale, respectively. A joint latent profile analysis was performed using the six ratings of worst pain severity and sleep disturbance. Parametric and non-parametric tests were used to evaluate for differences in modifiable and non-modifiable risk factors between the profiles.

resultsTwo subgroups of patients with distinct joint pain and sleep disturbance profiles were identified (i.e., Moderate Pain and Sleep Disturbance (Both Moderate, 53.4%) and Severe Pain and Sleep Disturbance (Both Severe, 46.6%)). Compared to the Both Moderate class, patients in Both Severe class were younger, female, had lower level of education, were unemployed, and had a lower annual income. In addition, they had a higher comorbidity burden and a lower functional status. The Both Severe class had problems with sleep initiation and maintenance.

conclusionsA significant proportion of patients receiving chemotherapy experience the co-occurrence of severe pain and sleep disturbance. Oncology clinicians need to work with primary care providers to optimize the management of these two symptoms.

Indexed as

Antineoplastic AgentsArthralgiaCancer PainNeoplasmsSleep Wake DisordersAdultAgedAge FactorsComorbidityFemaleHumansMaleMiddle AgedOutpatientsPain MeasurementRisk FactorsAntineoplastic AgentsCancerChemotherapyInsomniaMultimorbidityPainPain interferencePain qualitiesSleep disturbance

Identifiers

PMID41258510
PMCPMC12630231

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.