Evidence map›Paper›PMID 41258498›Full record

ArticleScientific reports2025

Pharmacokinetics and abbreviated AUC model of enteric-coated mycophenolate sodium in early kidney transplant recipients receiving tacrolimus.

Tanat Lertussavavivat, Napatsanan Tanathitiphuwarat, Chanyanuch Rakpithayanon, Suwasin Udomkarnjananun, Thunyatorn Wuttiputhanun, Somratai Vadcharavivad, Yingyos Avihingsanon, Somchai Eiam-Ong, Kearkiat Praditpornsilpa, Pajaree Chariyavilaskul and 1 more

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tanat LertussavavivatDepartment of Pharmacology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Napatsanan TanathitiphuwaratCenter of Excellence in Clinical Pharmacokinetics and Pharmacogenomics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Chanyanuch RakpithayanonDivision of Nephrology, Department of Medicine, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand.
Suwasin UdomkarnjananunDivision of Nephrology, Department of Medicine, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand.
Thunyatorn WuttiputhanunDivision of Nephrology, Department of Medicine, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand.
Somratai VadcharavivadDepartment of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
Yingyos AvihingsanonDivision of Nephrology, Department of Medicine, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand.
Somchai Eiam-OngDivision of Nephrology, Department of Medicine, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand.
Kearkiat PraditpornsilpaDivision of Nephrology, Department of Medicine, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand.
Pajaree ChariyavilaskulDepartment of Pharmacology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Natavudh TownamchaiDivision of Nephrology, Department of Medicine, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand. ntownamchai@gmail.com.

Funding

National Research Council of Thailand NRCT5-RSA63001-02Ratchadapisek Somphot Fund, Faculty of Medicine, Chulalongkorn University RA-MF-22/67
6 · The paper itself

Abstract

Enteric-coated mycophenolate sodium (EC-MPS) is used in kidney transplant recipients (KTRs) as an alternative to mycophenolate mofetil for improved gastrointestinal tolerability. However, its variable absorption complicates therapeutic drug monitoring (TDM), and pharmacokinetic data in the early post-transplant period remain limited. In this single-center, open-label pharmacokinetic study, 20 kidney transplant recipients (KTRs) receiving EC-MPS with tacrolimus underwent 12-h plasma mycophenolic acid (MPA) concentration profiling on day 3 post-transplantation. The full area under the curve (AUC

Indexed as

Immunosuppressive AgentsKidney TransplantationMycophenolic AcidTacrolimusAdultAgedArea Under CurveDrug MonitoringFemaleHumansMaleMiddle AgedTablets, Enteric-CoatedTransplant RecipientsImmunosuppressive AgentsMycophenolic AcidTablets, Enteric-CoatedTacrolimus

Identifiers

PMID41258498
PMCPMC12630578

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.