Evidence map›Paper›PMID 41258380›Full record

ArticleProbiotics and antimicrobial proteins2026

Non-targeted Metabolomic and Intestinal Microbiota Analysis of Ligilactobacillus salivarius X9 in Enterotoxigenic Escherichia coli K88-induced Enteritis in Mice.

Weixue Meng, Nan Dai, Leiyilan Wen, Tajin Wang, Lei Qu, Lili Guan, Jingrui Chen, Lingcong Kong, Hongxia Ma, Haipeng Zhang

Abstract read
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In one paragraph

Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Weixue Meng *College of Life Science, Jilin Agricultural University, Xincheng Street No. 2888, Changchun, 130118, China.
Nan Dai *College of Life Science, Jilin Agricultural University, Xincheng Street No. 2888, Changchun, 130118, China.
Leiyilan WenCollege of Life Science, Jilin Agricultural University, Xincheng Street No. 2888, Changchun, 130118, China.
Tajin WangCollege of Life Science, Jilin Agricultural University, Xincheng Street No. 2888, Changchun, 130118, China.
Lei QuInstitute of Animal Husbandry and Veterinary Medicine, Jilin Academy of Agricultural Science, Kemao Street No. 186, Gongzhuling, 136100, China.
Lili GuanCollege of Life Science, Jilin Agricultural University, Xincheng Street No. 2888, Changchun, 130118, China.
Jingrui ChenCollege of Life Science, Jilin Agricultural University, Xincheng Street No. 2888, Changchun, 130118, China.
Lingcong KongCollege of Veterinary Medicine, Jilin Agricultural University, Xincheng Street No. 2888, Changchun, 130118, China.
Hongxia MaCollege of Life Science, Jilin Agricultural University, Xincheng Street No. 2888, Changchun, 130118, China. hongxia0731001@163.com.
Haipeng ZhangCollege of Life Science, Jilin Agricultural University, Xincheng Street No. 2888, Changchun, 130118, China. zhanghaipeng211@163.com.

Funding

the National Natural Science Foundation of China 32302932
6 · The paper itself

Abstract

Enterotoxigenic Escherichia coli K88 (ETEC K88), a member of the E. coli family, poses a serious threat to human health and animal husbandry due to its high morbidity and mortality rates. Herein, three strains of lactic acid bacteria were isolated from the feces of Luhua chickens raised on farms in the Inner Mongolia Autonomous Region, China. Their antibacterial spectrum, acid resistance, bile salt resistance, antibiotic sensitivity, and other biological characteristics were evaluated. The results showed that Ligilactobacillus salivarius X9 (L. salivarius X9) exhibited superior acid and bile salt tolerance, favorable safety properties, and the strongest antibacterial activity against multidrug-resistance ETEC K88. Therefore, this study evaluated whether L. salivarius X9 could mitigate intestinal inflammatory damage induced by ETEC K88 in mice. The results showed that IL-1β levels were significantly reduced in the L. salivarius X9 treatment group compared with the intragastric ETEC K88 model group (GI group), while IL-10 levels were significantly upregulated in the treatment group. In addition, preconditioning with L. salivarius X9 increased the relative abundance of gut probiotics, regulated the accumulation of L-arginine and stearic acid, alleviated morphological damage in the mouse ileum induced by ETEC K88, and prevented intestinal inflammation. Our findings provide a foundation for the clinical application of L. salivarius X9 in the prevention of intestinal inflammation caused by ETEC K88.

Indexed as

EnteritisEnterotoxigenic Escherichia coliEscherichia coli InfectionsGastrointestinal MicrobiomeLigilactobacillus salivariusProbioticsAnimalsChickensFecesFemaleMaleMetabolomicsMiceEnterotoxigenic Escherichia coli K88Inflammatory factorIntestinal microbial communityLigilactobacillus salivarius X9Metabolomics

Identifiers

PMID41258380

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.