ArticleProbiotics and antimicrobial proteins2026
Antibacterial and Antibiofilm Activities of Postbiotics Produced by Lactobacillus Rhamnosus KC3 Isolated from Camel Milk Against CR-APEC and MRSA, and Their Synergistic Effects with β-Lactam Antibiotics.
Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Unraveling the Microbial Associations of Volatile Flavor Profiles in Spontaneously Fermented Camel Milk from Three Regions of Xinjiang, China.Foods (Basel, Switzerland) · 2026Article
- Bacteriocins in Veterinary Medicine: From Antibiotic Limitations to Targeted Solutions.International journal of molecular sciences · 2026Review
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Authors and funding
7 authors.
Funding
Abstract
Carbapenem-resistant avian pathogenic Escherichia coli (CR-APEC) and methicillin-resistant Staphylococcus aureus (MRSA) caused significant economic losses due to biofilm and drug resistance, and Lactic acid bacteria (LAB) are potentially valuable in livestock breeding, biocontrol, and mitigation of drug resistance. In this study, Lactobacillus rhamnosus KC3 (L. rhamnosus KC3) was isolated from raw milk of healthy camels in Xinjiang, China. We then evaluated the antibacterial and antibiofilm activities of L. rhamnosus KC3 postbiotics against CR-APEC and MRSA, as well as their synergistic effects with antibiotics. Additionally, the antimicrobial compounds and their biosynthetic pathways in L. rhamnosus KC3 were characterized through enzymatic assays and genomic analysis. The results showed that L. rhamnosus KC3 postbiotics exhibited broad-spectrum antibacterial activity against eight common pathogenic bacteria (MIC = 31.25 ± 0 mg/mL), including CR-APEC and MRSA. Notably, they significantly enhanced the efficacy of β-lactam antibiotics against these resistant pathogens (FIC < 0.5), indicating strong synergy. Furthermore, at a subinhibitory concentration, L. rhamnosus KC3 postbiotics suppressed biofilm formation by more than 25% (P ≤ 0.05). Enzyme treatment revealed that L. rhamnosus KC3 may exert bacteriostatic activity through the secretion of bacteriocins, and genome analysis also indicated that its genome contains a complete gene cluster and synthesis pathway for novel IIc bacteriocins. In conclusion, this study demonstrated that L. rhamnosus KC3 from camel milk had the characteristics of antibacterial, antibiofilm, and synergistic effects with antibiotics. This strain can provide resources of microorganisms and genetic information for the novel bacteriocins discovery and application.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.