SynthesisMolecular psychiatry2026
Molecular and topographic mapping of antipsychotic effects: a meta-analysis of postsynaptic density proteins in animal models with translational implications.
Synthesis in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
11 authors.
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Abstract
backgroundWhile antipsychotics primarily target dopamine D
methodsWe systematically reviewed and meta-analyzed peer-reviewed preclinical studies reporting quantitative effects of typical and atypical antipsychotics on PSD-related outcomes. Statistical analyses used random-effects models, with heterogeneity assessed via τ², I², and Cochran's Q. Separate meta-analyses were conducted for PSD protein type, brain region, animal type, and treatment paradigms. Meta-regressions assessed the impact of cofounding variables.
resultsWe included 81 studies (n = 2542; rodents=2510; monkeys=26), resulting in 226 meta-analyses. Both typical and atypical antipsychotics modulated PSD molecules albeit with different degree due to the drug receptor profile, dose, specific protein detected, brain region, and administration regimen. Haloperidol, amisulpride, and aripiprazole significantly increased PSD protein expression in the striatum. Acute olanzapine increased PSD molecules levels in striatal regions, reducing Arc expression in frontal cortex (SMD [95%CIs]=-2.15 [-2.7;-1.61], p < 0.0001); chronic treatment had opposite effects. Clozapine increased Homer1a levels in dorsal (1.13 [0.41;1.86], p = 0.002) and ventral striatum (1.48 [0.72;2.24], p = 0.0001), and cingulate cortex (2.12 [1.12;3.12], p < 0.0001), as well as increased NMDAR subunits levels in frontal cortex.
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