Evidence map›Paper›PMID 41258310›Full record

ArticleMolecular neurobiology2025

Stereotaxic Delivery of M1000 Prions to the Hippocampus Induces Related Behavioural and Cognitive Changes Consistent with Acute Neurotoxic Effects.

Matteo Senesi, Victoria Lewis, Paul A Adlard, David I Finkelstein, Jee Hyun Kim, Steven J Collins

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Matteo SenesiDepartment of Medicine, The University of Melbourne, Parkville, Melbourne, VIC, 3052, Australia.
Victoria LewisDepartment of Medicine, The University of Melbourne, Parkville, Melbourne, VIC, 3052, Australia.
Paul A AdlardThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Melbourne, VIC, 3052, Australia.
David I FinkelsteinThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Melbourne, VIC, 3052, Australia.
Jee Hyun KimThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Melbourne, VIC, 3052, Australia.
Steven J CollinsDepartment of Medicine, The University of Melbourne, Parkville, Melbourne, VIC, 3052, Australia. s.collins@unimelb.edu.au.

Funding

National Health and Medical Research Council APP1083309National Health and Medical Research Council APP1105784
6 · The paper itself

Abstract

Prion diseases are fatal neurodegenerative disorders characterised by the misfolding of the normal prion protein (PrP

Indexed as

Behavior, AnimalCognitionHippocampusPrionsStereotaxic TechniquesAnimalsExploratory BehaviorFearMaleMaze LearningMiceMice, Inbred C57BLPrion DiseasesPrionsAnimal behaviourAssociative learningHippocampusInfectious diseasesMemoryNeurodegenerationPrionSpatial learning

Identifiers

PMID41258310

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.