ArticleScientific reports2025
Genomic characterization of novel lytic phage vB_Sal_S6 with putative host FhuA interaction and its application for Salmonella biocontrol in milk.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Global foodborne Salmonella outbreaks pose a serious concern for food safety and public health underscoring the need for isolation of lytic phages with potential as biocontrol agents. A lytic bacteriophage vB_Sal_S6 was isolated which targets Salmonella serovars - Typhimurium, Bovismorbificans, Infantis, Typhi, Paratyphi, Weltevreden, Poona and as well as Escherichia coli. It exhibited strong bacteriolytic activity across a range of MOIs (0.01-10), with stability across pH 4-10 and temperature conditions (25-55 °C). In artificially contaminated milk, vB_Sal_S6 reduced Salmonella counts by 3.9log at RT and 2.4log at 4 °C within 9 and 6 h respectively (MOI 10). Genomic characterization revealed a dsDNA genome of 36,127 bp length and the absence of virulence, integrase, excisionase, and antibiotic resistance genes, supporting its suitability for biocontrol. Phylogenetic analysis indicated that vB_Sal_S6 clustered with other Salmonella/E.coli phages in Tequintavirus genus within Demerecviridae family. Docking studies identified that ORF123-encoded receptor-binding tail protein binds with ferrichrome receptor FhuA in Salmonella and E.coli as putative receptor. These findings establish vB_Sal_S6 as a promising candidate for biocontrol applications against Salmonella and E. coli.
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