ArticleExtremophiles : life under extreme conditions2025
Antitumor potential of glutaminase- and urease-free L-asparaginase from Antarctic fungus Mortierella turficola.
Article in Extremophiles : life under extreme conditions, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- L-asparaginase by filamentous fungi and yeasts from lichens and soils across maritime Antarctic islands.Extremophiles : life under extreme conditions · 2026Article
- Antioxidant, Anti-Inflammatory and Anticancer Peptides from Extreme Marine Environments.Antioxidants (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
L-Asparaginase (L-ASNase) is a chemotherapy drug that has been used as a therapy for the treatment of some types of cancer, including leukemia and lymphoma. Its action involves inhibiting the growth of tumor cells by reducing the availability of asparagine in the body. L-ASNase is an enzyme produced by microorganisms; however, they have adverse effects, which may be related to the activities of glutaminase and urease. Bioprospecting in cold environments, such as the Antarctic continent, may be a promising alternative in the search for enzymes with differentiated properties. For these reasons, the present study evaluated the production of glutaminase- and urease-free L-asparaginase by fungi isolated from soil and wood collected on two islands of the South Shetland Archipelago, Antarctica. A total of 39 filamentous fungi were recovered. Mortierella turficola FM2.1, isolated from wood, produced only L-asparaginase in a solid culture medium assay, showing an enzymatic index of 2.83. The effects of enzymatic extracts on HBMEC, MRC-5, and MIAPaCa-2 cell lines were investigated. MTT assay showed IC
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Registered trials
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