ArticleJournal of anesthesia, analgesia and critical care2025
Application of active subglottic airway humidification in intermittent subglottic secretion drainage in patients with tracheostomy: a randomized controlled trial.
Article in Journal of anesthesia, analgesia and critical care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundIntermittent aspiration of subglottic secretions (IASS) is commonly used to alleviate retention on the cuff, but inappropriate subglottic secretion drainage may lead to adverse effects, and fewer studies have been conducted on active subglottic airway humidification to improve the safety and effectiveness of IASS.
methodsA randomized controlled trial was conducted from August 2023 to July 2024, involving 90 patients with flushable tracheostomy tubes: 48 patients received 30-min pre-drainage active humidification (intervention group), while 42 patients received sterile water flush (control group). The outcomes included vital signs, secretion viscosity, cuff pressure, inspired and exhaled tidal volume, catheter blockage, occult blood positivity, and the incidence of ventilator-associated pneumonia (VAP).
resultsThe control group demonstrated a higher incidence of occult blood positivity (23.81% vs. 8.33%), blockage rate of the drainage catheter (19.05% vs. 4.17%), and Δcuff pressure (2.90 ± 1.39 cmH
conclusionActive subglottic airway humidification prior to IASS significantly reduces the positive rate of occult blood (OB) tests, the incidence of drainage catheter blockage, and secretion viscosity, with the exception of the incidence of VAP. It also stabilizes cuff pressure with minimal fluctuation. Although the intervention is associated with a decrease in exhaled tidal volume, it has no significant impact on pulse oxygen saturation or end-tidal carbon dioxide pressure.
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