Evidence map›Paper›PMID 41258195›Full record

Articlenpj aging2025

Solitary eating is linked to reduced brain volume in cognitively unimpaired individuals and possible future cognitive decline.

Mikana Isa, Kenjiro Ono, Moeko Noguchi-Shinohara, Mai Ishimiya-Jokaji, Kentaro Ide, Toshihiro Kawano, Shusuke Tokuchi, Risako Suzuki, Makoto Murahashi, Edward Hosea Ntege and 3 more

Abstract read
In one paragraph

Article in npj aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mikana IsaDepartment of Oral and Maxillofacial Surgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Kenjiro Ono *Department of Neurology and Neurobiology of Aging and Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.ORCID http://orcid.org/0000-0001-8454-6155
Moeko Noguchi-ShinoharaDepartment of Neurology and Neurobiology of Aging and Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
Mai Ishimiya-JokajiDepartment of Oral and Maxillofacial Surgery, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
Kentaro IdeDepartment of Oral and Maxillofacial Surgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Toshihiro KawanoDepartment of Oral and Maxillofacial Surgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Shusuke TokuchiDepartment of Oral and Maxillofacial Surgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Risako SuzukiDepartment of Oral and Maxillofacial Surgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Makoto MurahashiDepartment of Oral and Maxillofacial Surgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Edward Hosea NtegeDepartment of Oral and Maxillofacial Surgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Yusuke ShimizuPlastic and Reconstructive Surgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Shuichi KawashiriDepartment of Oral and Maxillofacial Surgery, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
Hiroyuki Nakamura *Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan. hnak@me.com.ORCID http://orcid.org/0000-0002-2524-3063

Funding

8020 Promotion Foundation 24-2-03
6 · The paper itself

Abstract

Social isolation and poor nutrition are recognized risk factors for cognitive decline in older adults. However, the relationship between solitary eating, brain structure, and dietary patterns remains unclear. This study investigated the relationship between solitary eating, brain structure, and diet in healthy older Japanese adults. A total of 727 cognitively normal participants (mean age 70.32 years) underwent MRI and dietary assessments. Results showed that individuals who frequently eat alone have reduced brain volumes in regions critical for cognitive function, particularly the medial temporal lobe and hippocampus. These individuals also demonstrated less healthy dietary patterns, characterized by higher sugar and alcohol consumption, with lower intake of proteins, vitamins, and minerals. Analysis revealed that the difference in hippocampal volume between solitary and social eaters diminished when accounting for dietary factors, suggesting that nutritional factors primarily drive this relationship. However, the difference in medial temporal lobe volume remained significant after dietary adjustment, indicating that other factors, such as reduced social interaction, may affect this region. These findings emphasize the importance of social eating for maintaining brain health in older adults, suggesting that both social and nutritional aspects of eating are crucial. This research provides insights for developing healthy aging strategies that address both social and nutritional dimensions of eating behavior.

Identifiers

PMID41258195
PMCPMC12630868

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.