Evidence map›Paper›PMID 41258194›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Association between return-to-work trajectories and depressive symptoms in long-term breast cancer survivors: results from the French CONSTANCES cohort.

Clémence Rapicault, Bertrand Porro, Julie Gourmelen, Céline Ribet, Anne-Lise Rolland, Yves Roquelaure, Mélanie Bertin

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Clémence RapicaultUniv. Angers, Univ. Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement Et Travail) - UMR_S 1085, SFR ICAT, SIRIC ILIAD, 49000, Angers, France.
Bertrand PorroUniv. Angers, Univ. Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement Et Travail) - UMR_S 1085, SFR ICAT, SIRIC ILIAD, 49000, Angers, France.
Julie GourmelenUniversité Paris Cité, Paris Saclay University, Université de Versailles Saint-Quentin-en-Yvelines, INSERM, UMS 011 « Population-based Cohorts Unit », Paris, France.
Céline RibetUniversité Paris Cité, Paris Saclay University, Université de Versailles Saint-Quentin-en-Yvelines, INSERM, UMS 011 « Population-based Cohorts Unit », Paris, France.
Anne-Lise RollandDépartement d'Information Médicale, Centre Hospitalier de Saint-Brieuc, 22000, Saint-Brieuc, France.
Yves RoquelaureUniv. Angers, CHU Angers, Univ. Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement Et Travail) - UMR_S 1085, SFR ICAT, SIRIC ILIAD, 49000, Angers, France.
Mélanie BertinUniv Rennes, EHESP, CNRS, Inserm, Arènes - UMR 6051, RSMS (Recherche Sur Les Services Et Management en Santé) - U 1309, F-35000, Rennes, France. melanie.bertin@ehesp.fr.ORCID http://orcid.org/0000-0001-9683-6256

Funding

Institut National Du Cancer INCa-DGOS-Inserm_12558
6 · The paper itself

Abstract

purposeDepressive symptoms (DS) are common in patients with breast cancer (BC). Our aim was to assess the association between return-to-work (RTW) trajectories and DS in long-term BC survivors (BCS) (≥ 5 years after diagnosis) in France.

methodsThe French population-based CONSTANCES cohort was linked to the national retirement insurance (CNAV) and national health insurance system (SNDS) databases. RTW trajectories were identified and categorized using the sequence analysis method and clustering. DS were assessed with the 20-item Center for Epidemiological Studies-Depression (CES-D) scale. The association between RTW trajectories and DS was analyzed with adjusted logistic regressions and statistical analyses were stratified according to the time from BC diagnosis to CES-D completion (i.e. < 5 or ≥ 5 years after BC diagnosis).

resultsDS (CES-D score > 20) was observed in 22.7% in the < 5 years CES-D group and 20.2% in the ≥ 5 years CES-D group. Three RTW trajectory patterns were identified: sustainable RTW (n = 203), unemployment and work transitions (n = 138), and disability worker status (n = 83). Compared with the sustainable RTW group, DS risk was higher in the disability worker status group (< 5 years post-diagnosis: OR [95% CI]: 3.22 [1.46;7.17] and ≥ 5 years post-diagnosis: 3.88 [1.13; 14.1]) and in the unemployment and work transitions group (< 5 years post-diagnosis: OR [95% CI]: 1.68 [0.81; 3.49], not significant). In this group, risk decreased after 5 years (OR [95% CI]: 0.19 [0.03; 0.88]).

conclusionReturning to work or pursuing new professional opportunities after BC may reduce the risk of long-term DS. IMPLICATIONS FOR CANCER SURVIVORS: DS may persist for an extended period after BC diagnosis. Engaging in sustainable RTW and exploring new professional opportunities contribute to supporting long-term psychological well-being and reduce the risk of persistent depressive symptoms in BCS.

Indexed as

Breast NeoplasmsCancer SurvivorsDepressionReturn to WorkUnemploymentAdultCohort StudiesFemaleFranceHumansMiddle AgedPsychological Well-BeingSelf ReportTime FactorsBreast cancerDepressive symptomsMental health and survivorshipReturn-to-workTrajectory

Identifiers

PMID41258194

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.