ArticleScientific reports2025
The protective role of appendicular lean mass in osteoporosis development among postmenopausal type 2 diabetes patients.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study aimed to explore the relationship between appendicular lean mass (ALM), osteoporosis (OP), and fracture risk in postmenopausal patients with type 2 diabetes mellitus (T2DM). A total of 1418 hospitalized postmenopausal patients with T2DM were enrolled. Bone mineral density (BMD) and ALM were measured using dual-energy X-ray absorptiometry (DXA). Based on BMD T-values, patients were categorized into OP and non-OP groups. General demographic data, biochemical markers, and body composition indices were compared between groups. Logistic regression analysis, nomogram construction, and receiver operating characteristic (ROC) curve analysis were performed to identify predictors and assess model performance. The prevalence of OP was significantly higher in patients with sarcopenia (SAC) compared to those without (P < 0.05). Significant between-group differences were observed in age, heart rate, 25-hydroxyvitamin D, height, weight, BMI, systolic blood pressure, presence of peripheral neuropathy, lymphocyte count, LDL cholesterol, total cholesterol, alanine aminotransferase, albumin, uric acid, creatinine, β-CTX, ALM/Ht
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