ArticlePlant cell reports2025
BjZIP1, a plasma membrane-localized transporter, mediates cadmium and zinc uptake in Brassica juncea.
Article in Plant cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
key messageBjZIP1 is a plasma membrane-localized protein. Overexpression of BjZIP1 in yeast, Arabidopsis thaliana, and Brassica juncea hairy roots confirmed its role in promoting Cd/Zn uptake. Heavy metal contamination in agricultural soils significantly threatens global food security. While Brassica juncea is recognized as a promising hyperaccumulator for phytoremediation, the specific transporters mediating its metal uptake remain largely unexplored. Here, we identify BjZIP1, a plasma membrane-localized protein that functions as a transporter for cadmium (Cd) and zinc (Zn) uptake in B. juncea. Heterologous expression of BjZIP1 in Cd-sensitive yeast mutant (Δyap1) increased intracellular accumulation of Cd and Zn by 17.8% and 25.0%, respectively, and consequently enhanced metal sensitivity. In Arabidopsis thaliana, BjZIP1 overexpression lines accumulated 31.1-58.3% more Cd and 1.68-2.48-fold higher Zn in roots under metal stress, which was accompanied by a growth inhibition phenotype. Crucially, BjZIP1-overexpressing B. juncea hairy roots accumulated 1.05-1.30-fold more Cd and 1.42-1.92-fold more Zn, alongside a concomitant exacerbation of cellular damage under Cd exposure. Collectively, our results establish BjZIP1 as a plasma membrane transporter responsible for Cd and Zn uptake in B. juncea, thereby providing a promising molecular target for genetic enhancement of phytoremediation efficiency.
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