ArticleBMC research notes2025
The influence of dopamine receptor SNPs on substance use disorder in a Jordanian cohort.
Article in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
Abstract
objectiveGenetic factors are known to contribute to the development and progression of substance use disorder (SUD). Genes associated with dopamine-mediated reward pathways play a critical role in SUD. This study aimed to investigate the association of specific single nucleotide polymorphisms (SNPs) within the DRD1, DRD2, DRD3, DRD4, and DRD5 genes with SUD in a population of Jordanian males.
resultsA significant association was observed between the rs686 SNP and SUD, with the GG genotype showing a statistically significant association with SUD onset. The rs6280 (T > C) SNP in the DRD3 gene was significantly associated with SUD, as evidenced by both genotypic and allelic frequency analyses. Furthermore, the CG haplotype (rs4532, rs686) of DRD1 and the ACG haplotype (rs936461, rs936460, rs936465) of DRD4 were significantly associated with SUD onset, suggesting their potential roles as genetic risk factors. Multinomial logistic regression analysis identified smoking and marital status as factors significantly associated with the studied genotypes, further increasing the risk of SUD.
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