ArticleScientific reports2025
Exploring the binding of cinchonine with human transferrin: combined experimental and computational approaches.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Neurodegenerative diseases (NDs), like Alzheimer's disease (AD), present immense global health challenges, marked by progressive and irreversible neuronal loss. While many studies have reported the neuroprotective potential of various phytochemicals, the neurotherapeutic relevance of alkaloids, like cinchonine remains largely unexplored. This study for the first time investigates cinchonine, a natural Cinchona alkaloid with reported antioxidant, anti-inflammatory, and amyloid-inhibitory properties, for its interaction with human transferrin (hTf), a glycoprotein central to iron homeostasis and neuroprotection employing a combination of computational and experimental approaches. UV-Vis spectroscopy revealed significant changes in hTf's absorbance upon cinchonine binding, confirming stable protein-ligand complex formation, with a binding constant (K) of 0.7 × 10
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