ArticlePediatric nephrology (Berlin, Germany)2026
Comparison of health-related quality of life in children and adolescents with monosymptomatic nocturnal enuresis under therapy versus allergic bronchial asthma, diabetes mellitus type I, and juvenile idiopathic arthritis - a KINDL-R-based study.
Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMonosymptomatic nocturnal enuresis (MNE) affects 10-15% of children at school age. Influences on psychological well-being and self-confidence were repeatedly described, but effects on health-related quality of life (HRQoL) have been rarely reported. The aim of this study is to examine the HRQoL under therapy by using KINDL-R and to compare it with three recognized chronic diseases.
methodsQuestionnaires were sent to all patients with MNE of the special outpatient clinic for enuresis (age 7-17 years; groups: I: 7-13, II: 14-17 years; at least 3 months of therapy, no achieved dryness). Simultaneously, patients from special outpatient clinics for allergic bronchial asthma (ABA), diabetes mellitus type I (DMI), and juvenile idiopathic arthritis (JIA) were asked to take part in the study.
resultsIncluded patients: 47 MNE (I:41/II:6)/59 ABA (I:34/II:25)/57 DMI (I:31/II:26)/37 JIA (I:18/II:19). Patient reports showed no significant differences between the cohorts in both age groups examined with regard to the total score and six individual dimensions. In the additional "chronic-generic" module, patients with MNE in the age of 7-13 years showed significantly lower values than all other study cohorts (p < 0.001).
conclusionsPatients under therapy for MNE without achieving dryness showed no significant differences in overall HRQoL or individual dimensions compared to the reference groups, but a significantly lower HRQoL in the chronic-generic module in children and parents (group 7-13 years) and in adolescents (14-17 years of age). This result is consistent with reported limitations in self-esteem and HRQoL before therapy and supports the need and importance of adequate therapy for MNE.
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