Evidence map›Paper›PMID 41258070›Full record

ArticleScientific data2025

14,441 Genomics-Based Validated Automated Comprehensive Clinicopathologic Correlations for Myeloid Neoplasms.

Ahmed Elsafty, Yomna Ahmed, Taher F Halawa, Shaoguang Li, Dongguang Li, Elena Agranovsky, Ahmed Soliman, Howida Talaat, Mohamed Montaser, Omar Elnady and 52 more

Abstract readDataset
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific data, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

62 authors.

Ahmed ElsaftyPathOlOgics, LLC, Cairo, Egypt. aelnady777@hotmail.com.ORCID 0000-0002-7067-4962
Yomna AhmedPathOlOgics, LLC, Cairo, Egypt.ORCID 0009-0005-5843-0446
Taher F HalawaPediatric Hematology-Oncology Department, Aberdeen Hospital, Nova Scotia Health Authority, Halifax, Canada.
Shaoguang LiHematology/Oncology Division, Department of Medicine, Medical School, University of Massachusetts Chan, Worcester, MA, USA.
Dongguang LiHematology/Oncology Division, Department of Medicine, Medical School, University of Massachusetts Chan, Worcester, MA, USA.
Elena AgranovskyLenco Diagnostic Lab, NYC, Brooklyn, USA.
Ahmed SolimanPathOlOgics, LLC, Cairo, Egypt. a.m.montasser@outlook.com.
Howida TalaatPathOlOgics, LLC, Cairo, Egypt.
Mohamed MontaserPathOlOgics, LLC, Cairo, Egypt.ORCID 0009-0006-0368-7049
Omar ElnadyPathOlOgics, LLC, Cairo, Egypt.
Deyaa ElnadyDatabase Academy, Cairo, Egypt.
Mohamed Mahmoud MoustafaDepartment of Data Science, New Jersey Institute of Technology, Newark, USA.ORCID 0009-0006-1498-0099
Nourhan IbrahimAnatomic & Clinical Pathology Department, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, USA.
Maryana GumenyakNYC Health+Hospitals South Brooklyn Health, Brooklyn, NY, USA.
Yasmin SolimanGeriatric & Family Medicine Department, Dubai Academic Health Corporation, Dubai, UAE.
Samah AliPathology Department, University of Toledo Medical Center, Toledo, USA.
Elshaimaa AbdelrahmanPathology Department, The George Washington University, Washington, DC, USA.ORCID 0009-0007-8977-5855
Hatem M S AlahwalDepartment of Hematology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.ORCID 0000-0003-3961-0765
Ahmed S BarefahDepartment of Hematology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.ORCID 0000-0003-2009-3817
Ashraf AbdelghanyBiomedical Research Centre (CIBM), Granada Medical School, Granada, Spain.ORCID 0000-0001-8908-6266
Sherif AmmarObstetrics and Gynecology Department, Worcestershire Acute Hospitals NHS Trust, Worcester, UK.
Nermeen Abdel-HaleemRegional Laboratory, Taif, Saudi Arabia.
Osama Abdel-KareemOtolaryngology Department, Saudi German Hospitals, Jeddah, Saudi Arabia.
Samir N ShammaInstitute of Global Health & Human Ecology, School of Sciences & Engineering, The American University in Cairo, Cairo, Egypt.ORCID 0000-0003-3508-1130
Naglaa HuseinClinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Maha M SakrClinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.ORCID 0000-0001-7448-5221
Heba-Allah E AbdElrhmanClinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Menatalla NadimClinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.ORCID 0000-0003-1506-3613
Hany GirguisClinical Pathology Department, Children Cancer Hospital (CCHE) 57357, Cairo, Egypt.ORCID 0009-0000-3300-1155
Manal OthmanClinical Pathology Department, Al-Ahrar Teaching Hospital, Zagazig, Egypt.
Ola SolimanClinical Pathology Department, Al-Ahrar Teaching Hospital, Zagazig, Egypt.
Walaa H BeheryClinical Pathology Department, Al-Ahrar Teaching Hospital, Zagazig, Egypt.
Lamis EltoukhyClinical Pathology Department, Al-Ahrar Teaching Hospital, Zagazig, Egypt.
Heldez A MohamedClinical Pathology Department, Al-Ahrar Teaching Hospital, Zagazig, Egypt.
Aya M HassanClinical Pathology Department, Al-Ahrar Teaching Hospital, Zagazig, Egypt.
Fatma-Elzahraa A BebersClinical Pathology Department, Al-Ahrar Teaching Hospital, Zagazig, Egypt.
Marwa Abdel-ZaherClinical Pathology Department, Al-Ahrar Teaching Hospital, Zagazig, Egypt.
Sara A AbbasClinical Pathology Department, Al-Ahrar Teaching Hospital, Zagazig, Egypt.
Shady AttiaClinical Pathology Department, Al-Ahrar Teaching Hospital, Zagazig, Egypt.
Mohamed A SaadaClinical Pathology Department, Sheikh Zayed Al-Nahyan Hospital, Cairo, Egypt.
Amira S EidInternal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Soha E KhorshedTropical Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Khaled TalaatNephrology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Mohamed Saad Hamed MahmoudEndocrinology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Mahmoud M S MahmoudThe Specialized Endocrine Center, Roxy, Cairo, Egypt.
Ola M S MahmoudCardiovascular Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt.
Abdel-Rahman O Abdel-KareemCardiovascular Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Ahmed K TalaatCardiovascular Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Haitham HeneishCardiovascular Medicine Department, Wadi Elneel Hospital, Cairo, Egypt.
Ibrahim I SamahaSurgical Urology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.ORCID 0000-0003-2090-4309
Mones SafwatNeurosurgery Surgery Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Mohamed K TalaatPlastic Surgery Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Alaa O Abdel-KareemMicrobiology and Immunology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Hadeel Abdel-MonemMicrobiology and Immunology Department, Al-Ahrar Teaching Hospital, Zagazig, Egypt.
Ramy AbazaMinistry of Health, Cairo, Egypt.
Hazem AbazaMinistry of Health, Cairo, Egypt.
Nora AhmadMinistry of Health, Cairo, Egypt.
May A MaaroufMinistry of Health, Cairo, Egypt.
Iman A ShaheenClinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Ahmed S AbdelhafizClinical Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
Amera RabeeDermatopathology Department, eNovaderm Clinic, Nova Scotia Health Authority, Halifax, Canada.
Yara M MontaserGeriatric & Family Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt. yara.montaser@med.helwan.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The dataset (Elsafty_Reports_of_Myeloid_Neoplasms_2024) consists of 14,441 comprehensive clinicopathologic correlations (CPCs) for myeloid neoplasms (MN) with corresponding laboratory results. Specialized online platform utilizing these laboratory results automatically generated the diagnostic and prognostic CPCs. These results include complete blood counts (CBC), peripheral blood smear (PBS) findings, blast/promyelocyte count with dysplasia screening by flow cytometry, and molecular results by NGS/PCR. Two Hematopathologists, who performed the CBC and PBS review, collected their 10,794 real-world reports of cases served in Egypt with molecular studies performed in the USA and Europe. These newly-diagnosed cases included 243 chronic myeloid leukemia (CML) cases with 257 mutations/aberrations; 4,567 non-CML MN cases with 7,883 Tiers I/II mutations/aberrations, amino acid changes, and allele frequencies; and 5,984 benign/inconclusive cases with negative NGS for myeloid mutations/aberrations in 66 DNA/RNA genes. Additionally, there are 3,647 CPCs with synthetic genomics simulating all new/follow-up CML cases and complex/rare non-CML MN cases. Stringent validation by 51 international professors/consultants/specialists from multiple medical centres confirmed 100% medical and clerical accuracy, referencing the WHO 5th edition and relevant esteemed publications.

Indexed as

GenomicsLeukemia, Myelogenous, Chronic, BCR-ABL PositiveHumansMutation

Identifiers

PMID41258070
PMCPMC12630706

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.