Evidence map›Paper›PMID 41258058›Full record

ArticleMicrobiome2025

The pulmonary commensal Lactobacillus regulated lung γδ T cells to enhance resistance against bacterial infections.

Haochi Zhang, Xuemei Bao, Chunhe Li, Yanchen Liang, Na Pan, Yubing Fu, Bin Ma, Ting Wang, Jian Chen, Lipeng Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Research progress on T-cell responses inFrontiers in microbiology · 2026
    Pooled it
  2. Heat-killedResearch square · 2026
    Article
  3. Food science & nutrition · 2026
    Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Haochi ZhangState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, 010021, People's Republic of China.
Xuemei BaoState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, 010021, People's Republic of China.
Chunhe LiState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, 010021, People's Republic of China.
Yanchen LiangState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, 010021, People's Republic of China.
Na PanState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, 010021, People's Republic of China.
Yubing FuState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, 010021, People's Republic of China.
Bin MaState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, 010021, People's Republic of China.
Ting WangState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, 010021, People's Republic of China.
Jian ChenState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, 010021, People's Republic of China.
Lipeng ZhangAffiliated Hospital of Inner Mongolia Medical University, 010030, Hohhot, People's Republic of China.
Xiao WangState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, 010021, People's Republic of China. wangxiao@imu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPulmonary commensals play a crucial role in regulating host immune homeostasis and combating infections. Nevertheless, the deep mechanisms remain unclear.

resultsLong-term antibiotics pre-exposure enhanced the susceptibility to bacterial pneumonia, while intranasal reconstitution of the pulmonary microbiota mitigated these adverse effects, restoring host resilience to infections. We isolated two pulmonary commensals, Lactobacillus plantarum and Lactobacillus murinus, demonstrating that they induced IL-17A-mediated antibacterial immunity and promoted resistance to lung infections. Moreover, antibiotics-treatment reduced the frequency of pulmonary IL-17A secreting Vγ4

conclusionsIn this study, we report for the first time that pulmonary commensal Lactobacillus, specifically L. plantarum and L. murinus, activate Vγ4

Indexed as

Lactiplantibacillus plantarumLactobacillusLungPneumonia, BacterialAnimalsAnti-Bacterial AgentsInterleukin-17MiceMice, Inbred C57BLMicrobiotaPseudomonas aeruginosaPseudomonas InfectionsReceptors, Antigen, T-Cell, gamma-deltaStaphylococcus aureusSymbiosisAnti-Bacterial AgentsIl17a protein, mouseInterleukin-17Receptors, Antigen, T-Cell, gamma-deltaAntibioticsIL-17AInfectionPulmonary commensalsγδ T cells

Identifiers

PMID41258058
PMCPMC12628892

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.