ArticleJournal of ovarian research2025
Neuromedin B drives goat granulosa cell proliferation via NMBR-mediated calcium homeostasis.
Article in Journal of ovarian research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Mitochondrial CaFrontiers in cell and developmental biology · 2026Review
- Integrative single-cell and genomic analysis reveals NMB as a driver of metastatic adaptation in esophageal squamous cell carcinoma via metabolic rewiring and immune evasion.Frontiers in cell and developmental biology · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundNeuromedin B (NMB) has been implicated in the regulation of female reproductive functions, yet its precise role and underlying mechanisms in ovarian follicular development remain undefined. Granulosa cells (GCs), the principal functional cells within ovarian follicles, directly govern follicular growth and maturation through their proliferation and differentiation. In this study, we explored the regulatory effects and molecular mechanisms of NMB and its receptor neuromedin B receptor (NMBR) on goat GC proliferation.
resultsWe documented dynamic expression patterns of NMB and NMBR throughout ovarian and follicular development. Exogenous NMB treatment significantly enhanced GC proliferation, as evidenced by an increased fraction of S-phase cells and upregulation of CCNE1 and CDK1/2/6. Mechanistically, NMB bound to NMBR to activate phospholipase C β1 (PLCβ1), triggering endoplasmic reticulum (ER) Ca²⁺ release and significantly raising cytosolic Ca²⁺ levels while alleviating ER stress. Further analyses revealed that NMB strengthened mitochondria-associated ER membranes (MAMs) formation via the IRE1α–IP3R–VDAC1 axis, facilitating Ca²⁺ transfer into mitochondria. This led to enhanced mitochondrial function, including increased mitochondrial membrane potential, elevated respiratory chain complex activities, augmented ATP production, and promotion of mitochondrial network fusion. Importantly, these effects were abolished by an NMBR antagonist.
conclusionsThe molecular mechanism by which NMB-mediated activation of NMBR enhances mitochondrial metabolism through modulation of intracellular calcium homeostasis, thereby promoting proliferation of goat GCs. These findings shed new light on the regulation of follicular development and may inform strategies to improve reproductive efficiency in goats.
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