ArticleEuropean journal of medical research2025
Prognostic modeling and immune infiltration analysis in hepatocellular carcinoma using glutathione metabolism-associated genes.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- SLC25A39 Upregulation Is Associated with DNA Methylation, Immune Cell Infiltration, and Poor Prognosis in Hepatocellular Carcinoma.International journal of molecular sciences · 2026Article
- Widely Targeted Liver Metabolomics Reveals Potential Biomarkers in Mice with Drug-Induced Liver Injury.Metabolites · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundGlutathione (GSH) plays a central role in multiple physiological processes, including the maintenance of intracellular redox homeostasis and the detoxification of xenobiotics. While previous studies have linked GSH metabolism to the pathogenesis and treatment of hepatocellular carcinoma (HCC), systematic analysis of the expression profiles of GSH metabolism-related genes in HCC and their consistent correlation with patient prognosis remains insufficiently addressed.
methodsIn this study, the ribonucleic acid sequencing (RNA-seq) data and clinical information data of HCC were downloaded from public databases. Following Cox regression and consensus clustering analyses, three GSH metabolism-related subtypes with differential survival probability and immune infiltration status were identified in patients with HCC. Next, CDCA8, KIF20A, TRNP1, and ADH4 were chosen to establish a prognostic model.
resultsCompared with those in the low-risk group, patients with high-risk scores exhibited poor survival probability, higher immune scores, decreased benefit from immunotherapy and poor drug sensitivity.
conclusionsIn summary, this study established a prognostic risk model for HCC based on GSH metabolism-related genes, which could predict the prognosis and characterize immune infiltration status of HCC. This study may contribute to the identification of potential prognostic targets and the development of new clinical management strategies for HCC.
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