ArticleBMC research notes2025
Linalool as a potential agent against Toxoplasma gondii: an in vitro study.
Article in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
objectiveToxoplasmosis, caused by Toxoplasma gondii (T. gondii), is a common zoonotic disease worldwide. Novel therapeutic options are required due to the limited effectiveness and side effects of existing treatments. This study aims to evaluate the in vitro antiparasitic activity of linalool at various concentrations against tachyzoites of the T. gondii RH strain, in comparison with a positive control (saponin 0.2%) and a negative control (no treatment), using flow cytometric analysis.
resultsThe flow cytometry results revealed a dose-dependent anti-Toxoplasma activity for linalool, with 18.37%, 36.77%, 38.75%, 47.57%, and 50.63% mortality rates at the concentrations of 37.5, 75, 150, 300, and 600 µg/mL, respectively. The mortality rate at the concentration of 1200 µg/mL (74.44%) was slightly higher than that of the positive control group (67.87%). Our findings provide primary evidence for the extracellular potential of linalool against T. gondii tachyzoites. This study provides a rationale for further research to evaluate linalool's intracellular and in vivo efficacy and safety.
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