Evidence map›Paper›PMID 41257901›Full record

ArticleActa neuropathologica communications2025

Tau pathology in the brainstem monoaminergic neurons reflect resilience to Alzheimer's disease pathology in the Nun study cases.

Maryam Kherad Pezhouh, Gang Chen, Joyce Meints, Laura S Hemmy, Karen S SantaCruz, Michael K Lee

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In one paragraph

Article in Acta neuropathologica communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Maryam Kherad Pezhouh *Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA.
Gang Chen *Department of Neuroscience, University of Minnesota, Minneapolis, MN, 55455, USA.
Joyce MeintsDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, 55455, USA.
Laura S HemmyDepartment of Psychiatry, University of Minnesota, Minneapolis, MN, 55455, USA.
Karen S SantaCruzDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA. KSantaCruz@salud.unm.edu.
Michael K LeeDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, 55455, USA. mklee@umn.edu.

Funding

Abeta and Monoaminergic Neurodegeneration in Transgenic Mouse Models of ADR01AG029401 · NIA · UNIVERSITY OF MINNESOTA · PI LEE, MICHAEL K · 2009 to 2013
$1.5M
NIA NIH HHS R01 AG029401NIH HHS AG029401
6 · The paper itself

Abstract

The presence of amyloid and tau pathologies is the pathological hallmark of Alzheimer's disease (AD). However, the presence of non-demented individuals with sufficient AD pathology indicates that AD-linked pathology does not always lead to dementia. The current view is that a non-demented (ND) individual with sufficient AD pathology represents an individual resilient to AD pathology. To gain insight about resilience to AD pathology, we examined the neuropathology in the brainstem monoaminergic (MAergic) neurons in the Nun Study participants with equally high Braak AD stage (V-VI) with dementia and without clinical dementia. Because MAergic pathology is thought to occur in response to cortical AD pathology, any differences in MAergic pathology between the AD and ND groups with similarly advanced AD pathology could reflect the resilience of MAergic neurons to cortical AD pathology. Examination of Locus Coeruleus (LC) and/or Raphe for the presence of tau pathology showed that, despite the similar forebrain pathology, relative levels of perikaryal and neuritic tau pathology were significantly lower in ND than in AD subjects. The ND subjects exhibit greater pathology than control subjects without AD pathology, indicating that cortical AD pathology does impact subcortical neurons in both AD and ND cases. Significantly, the extent of neurodegenerative pathology in LC and Raphe neurons correlated with cognitive performance in AD cases, while no such correlation was seen in ND cases. Our results show that while cortical AD pathology is associated with increased MAergic neuropathology, quantitative differences in the extent of MAergic pathology in the brainstem may reflect underlying resistance to AD pathology.

Indexed as

Alzheimer DiseaseBiogenic MonoaminesBrain StemNeuronstau ProteinsAgedAged, 80 and overFemaleHumansLocus CoeruleusMaleMiddle AgedBiogenic MonoaminesMAPT protein, humantau ProteinsAlzheimer’s diseaseBrain reserveBrainstemCognitive reserveLocus coeruleusRaphe

Identifiers

PMID41257901
PMCPMC12629054

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.