ReviewReproductive biology and endocrinology : RB&E2025
The effects of testicular aging on Leydig cells and the application of stem cells in restoring Leydig cells function.
Review in Reproductive biology and endocrinology : RB&E, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Platelet-Derived Growth Factor Receptor Alpha in Male Reproductive Health and Oxidative Stress: Stromal Homeostasis, Injury, and Research Perspectives.Antioxidants (Basel, Switzerland) · 2026Review
- Combined Metabolomic and Transcriptomic Analysis Identifies Metabolic Signatures and Networks Associated with Semen Quality in Geese.Animals : an open access journal from MDPI · 2026Article
- Adipose-Derived Mesenchymal Stem Cells Alleviate ᴅ-Galactose-Induced Testicular Injury by Activating the Keap1/Nrf2 Pathway and Suppressing NLRP3-Associated Pyroptosis.Antioxidants (Basel, Switzerland) · 2026Article
- Metabolic Syndrome and Male Infertility: The Role of Obesity and Chronic Inflammation.Biomedicines · 2026Review
- Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the global population aging at an accelerated pace, testicular aging and its associated male health issues have garnered increasing attention. Testicular aging encompasses both age-related physiological decline and premature or pathological aging caused by various pathogenic factors. It is primarily characterized by reduced androgen secretion (mainly testosterone) and impaired spermatogenesis. Leydig cells, the key cells in the testes responsible for synthesizing and secreting testosterone, play a critical role in maintaining testicular function, and their dysfunction is one of the major contributors to testicular functional decline. In recent years, stem cell technology has demonstrated significant potential in restoring Leydig cell function. Stem cells possess the ability to differentiate into Leydig-like cells, which can restore testosterone secretion, improve the testicular microenvironment, and promote the regeneration of endogenous Leydig cells. Currently, various types of stem cells, such as stem leydig cells, mesenchymal stem cells, and induced pluripotent stem cells, have been successfully directed to differentiate into Leydig-like cells. This article provides an in-depth analysis of the mechanisms by which testicular aging affects Leydig cells, with a particular focus on the application of stem cell technology in restoring Leydig cell function. Additionally, it explores potential strategies to address these issues, aiming to offer novel perspectives and approaches for the prevention and treatment of testicular aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.