ArticleStem cell research & therapy2025
FGF21-engineered ADSCs promote diabetic wound healing by mitigating ferroptosis and oxidative stress via the SIRT1/NRF2/GPX4 signaling pathway.
Article in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Qigui didang decoction alleviates renal injury in a diabetic kidney disease model with metabolic memory features: association with ferroptosis and the SIRT1/Nrf2 pathway.Pharmaceutical biology · 2026Article
- Dihydroquercetin Activates AMPK/SIRT1/PGC-1α Signaling to Attenuate Arsenic Trioxide-Induced Apoptosis and Ferroptosis in AC16 Cells and HUVECs.International journal of molecular sciences · 2026Article
- Wound Healing Potential of Selenium and Nanoselenium.Biological trace element research · 2026Review
- Adipose-derived mesenchymal stromal cells and their acellular derivatives in cutaneous wound healing and pathological scarring: a narrative review.Cell and tissue banking · 2026Review
- Nrf2 Activators in Parkinson's Disease: Modulating Mitophagy and Regulating Cuproptosis.Molecular neurobiology · 2026Review
- Article
- ROS-responsive microneedle patch delivering NMN@Cu/CeO₂ nanozyme for restoring immune microenvironment and mitochondrial homeostasis to potentiate diabetic wound healing.Journal of nanobiotechnology · 2026Article
- Orchestrating diabetic wound repair via mitochondria-targeted delivery of dihydromyricetin with tailored ADSC-derived biohybrid nanovesicles.Materials today. Bio · 2026Article
- Autophagy-Ferroptosis Interplay Network: Redefining Therapeutic Paradigms for Diabetic Wound Healing.Journal of inflammation research · 2026Review
- Single-cell mapping of diabetic foot ulcers: mechanistic axes and therapeutic targets.Frontiers in medicine · 2026Review
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Authors and funding
13 authors.
Funding
Abstract
backgroundADSCs and growth factor-based therapies are widely investigated for diabetic wound healing. However, the clinical translation of ADSCs is limited by their biological instability under hyperglycemic conditions, while exogenous growth factors face challenges such as short half-life and high production costs. Here, we propose a novel strategy using FGF21-engineered ADSCs (ADSC
methodsTo investigate ferroptosis in diabetic wounds, we quantified iron accumulation, DNA oxidative damage (8-OHdG), and lipid peroxidation (MDA assay) in diabetic wound tissues. In vitro, high glucose (HG) treated HUVEC, a model for endothelial dysfunction, were subjected to 7-AAD staining, BODIPY C11-based lipid peroxidation assays, and transmission electron microscopy (TEM) to assess ferroptosis hallmarks. The therapeutic effects of ADSC
resultsWe demonstrated that hyperglycemia induces mitochondrial damage, lipid peroxidation, and ferroptosis in diabetic wounds and HG-treated HUVEC. By establishing FGF21-overexpressing ADSCs (ADSC
conclusionsOur study establishes ADSC
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