Evidence map›Paper›PMID 41257855›Full record

ReviewMalaria journal2025

Safeguarding artemisinin: integrating bioproduction innovation and resistance management for malaria eradication.

Karim Farmanpour Kalalagh, Ali Rezaei, Saeid Hazrati, Silvana Nicola, Sousan Moradi, Sanaz Davarpanah Dizaj, Neda Tariverdizadeh, Arman Beyraghdar Kashkooli

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Malaria journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Serological evidence of high exposure toMalariaWorld journal · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Karim Farmanpour KalalaghDepartment of Horticultural Science, Faculty of Agriculture, Tarbiat Modares University, P.O. Box 14115-336, Tehran, Iran.
Ali RezaeiDepartment of Horticultural Science, Faculty of Agriculture, Tarbiat Modares University, P.O. Box 14115-336, Tehran, Iran.
Saeid HazratiDepartment of Agronomy and Plant Breeding, Faculty of Agriculture, Azarbaijan Shahid Madani University, Tabriz, 5375171379, Iran.
Silvana NicolaDepartment of Agricultural, Forest and Food Sciences, Horticultural Sciences- Inhortosanitas Lab, University of Turin, 10095, Grugliasco, TO, Italy.
Sousan MoradiDepartment of Horticultural Science, Faculty of Agriculture, Tarbiat Modares University, P.O. Box 14115-336, Tehran, Iran.
Sanaz Davarpanah DizajDepartment of Horticultural Science, Faculty of Agriculture and Natural Resources, University of Mohaghegh Ardabili, Ardabil, Iran.
Neda TariverdizadehDepartment of Horticultural Science, Faculty of Agriculture and Natural Resources, University of Mohaghegh Ardabili, Ardabil, Iran.
Arman Beyraghdar KashkooliDepartment of Horticultural Science, Faculty of Agriculture, Tarbiat Modares University, P.O. Box 14115-336, Tehran, Iran. a.beyraghdar@modares.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malaria persists as a global health emergency, with Plasmodium falciparum resistance to artemisinin (ART) critically undermining elimination campaigns. This review consolidates dual challenges of ART production and resistance, presenting a unified analysis of countermeasures. The examination encompasses biotechnological advances in ART biosynthesis, including metabolic engineering strategies applied in both native and heterologous hosts, alongside an assessment of approaches to mitigate agricultural constraints in Artemisia annua cultivation. Concurrently, the analysis focuses on the molecular mechanisms underpinning ART resistance, with particular emphasis on pfk13 mutations and their implications for therapeutic efficacy. Current treatments, notably artemisinin-based combination therapy (ACT), and novel strategies like triple and quadruple ACTs (TACTs/QACTs) are critically evaluated, emphasizing advantages, drawbacks, and geographical suitability. By bridging production and resistance paradigms, this review outlines a sustainable malaria control roadmap, advocating interdisciplinary collaboration to ensure ART's enduring efficacy.

Indexed as

AntimalarialsArtemisininsDisease EradicationDrug ResistanceMalaria, FalciparumPlasmodium falciparumArtemisia annuaHumansAntimalarialsartemisininArtemisininsArtemisinin-based combination therapyArtemisinin resistanceMetabolic engineeringPfK13 mutationsPlasmodium falciparum

Identifiers

PMID41257855
PMCPMC12628914

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.