SynthesisJournal of orthopaedic surgery and research2025
Risk factors for new vertebral compression fracture following percutaneous vertebral augmentation: a systematic review and meta-analysis based on multivariate logistic regression analysis.
Synthesis in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Oral Food Supplement with Bio-Activated Silicium and Vitamins D3 and K2 in the Conservative Management of Osteoporotic Vertebral Compression Fractures.Journal of clinical medicine · 2026Article
- The role of nitrogen dioxide in the prevalence of adverse cardiovascular and cerebrovascular diseases in China: a national multi-pollutant geospatial analysis.BMC public health · 2026Article
- Frailty and sarcopenia as independent predictors of early functional recovery in older adults with osteoporotic vertebral compression fractures: a retrospective cohort study.Frontiers in nutrition · 2026Article
- Integrating core muscle morphology into a predictive model for residual back pain after vertebral augmentation.Frontiers in surgery · 2026Article
- Risk factors for subsequent vertebral fracture after percutaneous vertebroplasty in patients with osteoporotic vertebral compression fractures in Northern China.Frontiers in surgery · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
objectiveThis meta-analysis investigates the prevalence and risk factors for new vertebral compression fractures (NVCF) following percutaneous vertebral augmentation (PVA) in patients with osteoporotic vertebral compression fractures (OVCF).
methodsWe searched PubMed, Cochrane Library, Embase, and Web of Science (up to June 2025) and screened case-control and cohort studies that utilized multivariate logistic regression analysis to examine the prevalence and risk factors of NVCF after PVA in OVCF patients. The meta-analysis was performed according to the PRISMA guidelines. After data extraction, STATA 15.0 was used to calculate the pooled odds ratio (OR) and 95% confidence interval (CI).
resultsThis meta-analysis included 18 studies involving 7,743 patients, of whom 1,336 developed NVCF postoperatively, with a prevalence of 17.25%. The meta-analysis revealed that the risk factors for new fractures after PVA in OVCF patients were associated with Gender [OR = 1.99, 95%CI (1.50, 2.64), P < 0.001], Age [OR = 1.09, 95%CI (1.02, 1.17), P = 0.01], Bone mineral density (BMD) [OR = 0.74, 95%CI (0.63, 0.86), P < 0.001],Bone cement disc leakage [OR = 2.94, 95%CI (1.64, 5.28), P < 0.001], Lack of anti-osteoporosis treatment [OR = 2.93, 95%CI (2.14, 4.01), P < 0.001], Thoracolumbar junction (TL junction) [OR = 3.50, 95%CI (2.06, 5.93), P < 0.001], Hounsfield unit value (HU value) [OR = 0.96, 95%CI (0.95, 0.97), P < 0.001], Use of steroids [OR = 3.94, 95%CI (2.16, 7.21), P < 0.001], Number of initial fractures [OR = 2.21, 95%CI (1.17, 4.14), P = 0.01], Multiple vertebral fractures [OR = 1.71, 95%CI (1.14, 2.57), P = 0.01], Fracture history [OR = 7.72, 95%CI (3.09, 9.30), P < 0.001], Smoking [OR = 1.62, 95%CI (1.20, 2.19), P < 0.001], and Diabetes [OR = 1.98, 95%CI (1.50, 2.61), P < 0.001]. However, no association was found with Body mass index (BMI), Bone cement leakage, and Shape of bone cement.
conclusionThis study confirms that NVCF following PVA for OVCF is multifactorial, with most risk factors identifiable preoperatively. The clinical value of this knowledge lies in its application to guide postoperative prevention, thereby optimizing management quality through personalized follow-up and intervention.
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