Evidence map›Paper›PMID 41257810›Full record

ArticleJournal of ovarian research2025

SOAT1 in ovarian cancer cells regulates immune response mediated by CD8

Jiangnan He, Michelle K Y Siu, Runying Long, LingShan Hung, Ruiqian Zhang, Mingo M H Yung, Haonan Lu, Hextan Y S Ngan, Karen K L Chan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ovarian research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiangnan HeDepartments of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong, Hong Kong, Special Administrative Region of China.
Michelle K Y SiuDepartments of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong, Hong Kong, Special Administrative Region of China.
Runying LongDepartments of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong, Hong Kong, Special Administrative Region of China.
LingShan HungDepartments of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong, Hong Kong, Special Administrative Region of China.
Ruiqian ZhangDepartments of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong, Hong Kong, Special Administrative Region of China.
Mingo M H YungDepartments of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong, Hong Kong, Special Administrative Region of China.
Haonan LuDepartments of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong, Hong Kong, Special Administrative Region of China.
Hextan Y S NganDepartments of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong, Hong Kong, Special Administrative Region of China.
Karen K L ChanDepartments of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong, Hong Kong, Special Administrative Region of China. kklchan@hku.hk.

Funding

the University of Hong Kong No. 202011159187
6 · The paper itself

Abstract

backgroundSterol-O acyltransferase 1 (SOAT1) functions by converting cholesterol and acyl-CoA into cholesterol ester and CoA-SH. SOAT1 inhibition suppresses tumor growth. A recent study has shown that inhibiting cholesterol esterification in T cells using genetic manipulation or drug treatment of SOAT1 boosted the cytotoxicity of CD8

resultsCorrelation analysis results obtained using GEPIA2 showed that SOAT1 expression was positively correlated with cytotoxic CD8

conclusionIn conclusion, the present study suggested that SOAT1 inhibition in OC cells could impair the cytotoxic capability of CD8

Indexed as

CD8-Positive T-LymphocytesOvarian NeoplasmsSterol O-AcyltransferaseCell Line, TumorFemaleHumansTumor MicroenvironmentSterol O-Acyltransferasesterol O-acyltransferase 1CD8+ t cellCytotoxicityOvarian cancerSOAT1

Identifiers

PMID41257810
PMCPMC12628612

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.