Evidence map›Paper›PMID 41257700›Full record

ArticleBMC psychiatry2025

Working memory and its neural characteristics in male schizophrenia patients with or without a history of violent behavior: an exploratory fNIRS study.

Yu Gu, Huijuan Guo, Kai Liang, Yingxu Li, Gaoping Lai, Jie He, Tiejun Chen, Shaoling Zhong, Qiaoling Sun, Ying Huang and 5 more

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Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Yu GuDepartment of Psychiatry, National Center for Mental Disorders, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Huijuan GuoDepartment of Psychiatry, National Center for Mental Disorders, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Kai LiangThe Forensic Psychiatric Hospital of Hunan, Hunan, China.
Yingxu LiThe Forensic Psychiatric Hospital of Hunan, Hunan, China.
Gaoping LaiPingjiang County Psychiatric Hospital, Hunan, China.
Jie HeThe Ninth Hospital of Changsha, Hunan, China.
Tiejun ChenThe Ninth Hospital of Changsha, Hunan, China.
Shaoling ZhongDepartment of Community Mental Health, The Affiliated Brain Hospital of Guangzhou Medical University, 36 Mingxin Road, Liwan District, Guangzhou, 510370, China.
Qiaoling SunDepartment of Psychiatry, National Center for Mental Disorders, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Ying HuangDepartment of Psychiatry, National Center for Mental Disorders, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Jizhi WangDepartment of Psychiatry, National Center for Mental Disorders, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Siyuan WangPingtang Compulsory Isolation Detoxification Institute in Hunan Province, Hunan, China.
Yixin ZhaoDepartment of Psychiatry, National Center for Mental Disorders, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Jiansong ZhouDepartment of Psychiatry, National Center for Mental Disorders, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. zhoujs2003@csu.edu.cn.
Xiaoping WangDepartment of Psychiatry, National Center for Mental Disorders, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. xiaop6@csu.edu.cn.

Funding

Key Research and Development Program of Hunan Province 2023SK2028National Natural Science Foundation of China 82071543National Natural Science Foundation of China 82171509National Natural Science Foundation of China 82301741the Postdoctoral Fellowship Program of CPSF for Huijuan Guo GZC20233170
6 · The paper itself

Abstract

backgroundEvidence has suggested an association between working memory impairment and violence in people with schizophrenia. However, the neural characteristics of working memory deficit in this patient population remain unclear. This study aimed to examine the neurobiological differences in brain activity using the working memory task in schizophrenia patients with and without a history of violent behavior.

methodA total of 194 patients, including 106 with a history of severe violent behavior and 88 without such a history, as well as 66 healthy individuals, were recruited. All the participants were required to complete the n-back task (0-, 1-, and 2-back) under functional near-infrared spectroscopy.

resultsPatients with a history of violent behavior, but not those without, exhibited hyperactivity in the left dorsolateral prefrontal gyrus (all p < 0.05) and hypoactivity in the triangular part of the inferior frontal gyrus (all p < 0.05), as compared to healthy individuals. Compared to patient without a violent history, they demonstrated higher accuracy in 0- and 1-back tasks (both p < 0.001), however, their response times were also significantly prolonged (p < 0.001; p = 0.591).

conclusionThis study revealed severe damage to the overall working memory in schizophrenia patients with a history of violent behavior, with abnormal activation of brain regions related to working memory and semantic processing, accompanied by compensatory brain responses.

Indexed as

Dorsolateral Prefrontal CortexMemory, Short-TermSchizophreniaViolenceAdultHumansMaleMiddle AgedPrefrontal CortexSpectroscopy, Near-InfraredYoung AdultFunctional near infrared spectroscopy (fNIRS)n-backSchizophreniaViolent behaviorViolent crimeWorking memory

Identifiers

PMID41257700
PMCPMC12751973

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.