ArticleBMC pregnancy and childbirth2025
Association between maternal plasma glucose levels during pregnancy and risk of preterm birth: a retrospective study.
Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Drug-induced hyperglycemia in obstetrics: key offending drugs, mechanisms, and practical management.Frontiers in pharmacology · 2026Review
- Maternal Pre-Pregnancy Glycemic Status and Developmental Outcomes in Korean Children Aged 18-36 Months: A Nationwide Population-Based Cohort Study (2014-2021).Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
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15 authors.
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Abstract
backgroundPreterm birth is a leading cause of health problems and death in infants. This study aims to investigate the association between maternal plasma glucose levels during pregnancy and risk of preterm birth.
methodsThis population-based retrospective study of 6,842 pregnant women used data from a tertiary hospital in China from January 2016 to December 2022. Plasma glucose levels were measured at fasting, 1 h, and 2 h after a 75-g OGTT between 24 and 28 weeks of gestation. The primary outcome of interest was preterm birth. Analysis was performed using restricted cubic splines and logistic regression models.
resultsThe proportion of gestational diabetes mellitus (GDM) and preterm birth in this study were 7.92% and 5.86%, respectively. The levels of fasting plasma glucose (aOR: 1.26; 95% CI: 1.08, 1.47; P = 0.003; P for nonlinear = 0.264), 1-hour plasma glucose (aOR: 1.10; 95% CI: 1.03, 1.17; P = 0.003; P for nonlinear = 0.535), and 2-hour plasma glucose (aOR: 1.10; 95% CI: 1.02, 1.19; P = 0.012; P for nonlinear = 0.368) showed statistically significant linear associations with an increased risk of preterm birth.
conclusionElevated plasma glucose levels during pregnancy statistically significantly increase the risk of preterm birth. Given that hyperglycemia during pregnancy can be prevented and managed, it is crucial to enhance health education and glucose monitoring for pregnant women. Timely interventions should be implemented to control plasma glucose levels, thereby reducing the incidence of preterm birth.
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