Evidence map›Paper›PMID 41257649›Full record

Observational studyBMC ophthalmology2025

Anterior segment optical coherence tomography study of the cornea and tear film after systemic isotretinoin treatment in acne vulgaris.

Mohamed Salah El-Din Mahmoud, Hosny Ahmed Zein, Mustafa Mohamed Al-Anwar, Ahmed Maher Khalafallah

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mohamed Salah El-Din MahmoudOphthalmology Department, Faculty of Medicine, Minia University, Minia, Egypt. Mohamed_Zaki@mu.edu.eg.ORCID http://orcid.org/0000-0003-4537-2177
Hosny Ahmed ZeinOphthalmology Department, Faculty of Medicine, Minia University, Minia, Egypt.
Mustafa Mohamed Al-AnwarDermatology Department, Faculty of Medicine, Minia University, Minia, Egypt.
Ahmed Maher KhalafallahOphthalmology Department, Faculty of Medicine, Minia University, Minia, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeEvaluation of the precorneal tear film, CET, and CT by AS-OCT before and after treatment by oral isotretinoin in patients of acne vulgaris (AV).

methodsA prospective observational study was conducted on 100 eyes of 100 patients of AV at the Department of Ophthalmology, Minia University, Egypt. The patients were examined five times: before the start of treatment, after one month, after three months of treatment, and then after cessation of treatment by one and three months, with measurement of the tear film (TMA, TMD, and TMH), CET, and CT using the AS-OCT.

resultsRegarding tear film, there was a significant difference between the premedication TMH, TMA, and TMD and after one and three months of administration, followed by a significant improvement after cessation of treatment. Regarding corneal pachymetry, there were a significant changes in the total CT and CET after one and three months of administration, which improved after one and three months of drug cessation.

conclusionIsotretinoin treatment causes statistically significant changes in the tear film and corneal pachymetry, so clinicians should avoid performing any surgeries that require an accurate knowledge of corneal parameters at least 3 months after the cessation of treatment.

Indexed as

Acne VulgarisAnterior Eye SegmentCorneaDermatologic AgentsIsotretinoinTearsTomography, Optical CoherenceAdministration, OralAdolescentAdultCorneal PachymetryFemaleHumansMaleProspective StudiesYoung AdultDermatologic AgentsIsotretinoinAcne vulgarisAnterior segment optical coherence Tomography- Cornea-Tear filmIsotretinoin

Identifiers

PMID41257649
PMCPMC12629010

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.