Evidence map›Paper›PMID 41257630›Full record

ArticleBMC ophthalmology2025

Clinical manifestations and treatment prognosis of patients with co-infection of ocular syphilis and HIV.

Wenjun Kong, Fang Ruan, Lianyong Xie, Xia Feng, Yanqing Gao, Zhuyun Qian, Yong Tao

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Article in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Wenjun KongDepartment of Opthalmology, Beijing You'an Hospital, Capital Medical University, Beijing, China. drkongwenjun@163.com.
Fang RuanDepartment of Opthalmology, Beijing You'an Hospital, Capital Medical University, Beijing, China.
Lianyong XieDepartment of Opthalmology, Beijing You'an Hospital, Capital Medical University, Beijing, China.
Xia FengDepartment of Clinical Laboratory, Beijing You'an Hospital, Capital Medical University, Beijing, China.
Yanqing GaoDepartment of Dermatology, Candidate Branch of National Clinical Research Center for Skin Diseases, Beijing You'an Hospital, Capital Medical University, Beijing, China.
Zhuyun QianKey Laboratory Jointly Built by the National Institute for Viral Disease Control and Prevention of China Center for Disease Control and Prevention, Beijing GIANTMED Medical Diagnostics Laboratory, Beijing, China. qianzhuyun552@126.com.
Yong TaoDepartment of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. taoyong@mail.ccmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to evaluate the clinical manifestations and treatment prognosis of patients co-infected with ocular syphilis and HIV, focusing on ocular involvement subtypes and visual outcomes.

methodsA cohort of 31 patients (42 eyes) diagnosed with both ocular syphilis and HIV at Beijing You'an Hospital from January 2022 to March 2025 was analyzed. Diagnosis was confirmed through serological tests (TPPA, RPR) and ocular examinations. Patients received intravenous penicillin G followed by intramuscular benzathine penicillin. Best-corrected visual acuity (BCVA), ocular manifestations, and treatment responses were assessed.

resultsPosterior segment involvement was universal, with predominant subtypes being acute syphilitic posterior placoid chorioretinitis (13 eyes), confluent syphilitic retinochoroiditis (12 eyes), retinal vasculitis (4 eyes), and optic neuritis (13 eyes). BCVA improved significantly post-treatment. Optic neuritis showed better baseline and final BCVA, correlating with lower macular involvement.

conclusionsCo-infection of ocular syphilis and HIV predominantly affects the posterior segment, with optic neuritis exhibiting a distinct clinical profile. A comprehensive ocular and serological evaluations in high-risk populations is recommended.

Indexed as

CoinfectionEye Infections, BacterialHIV InfectionsSyphilisAdultAgedAnti-Bacterial AgentsFemaleHumansMaleMiddle AgedPenicillin G BenzathinePrognosisRetrospective StudiesTomography, Optical CoherenceVisual AcuityAnti-Bacterial AgentsPenicillin G BenzathineClinical manifestationsHIVOcular syphilisTreatment prognosisVisual outcomes

Identifiers

PMID41257630
PMCPMC12628631

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.