Evidence map›Paper›PMID 41257614›Full record

ArticleBMC infectious diseases2025

Concentration of contezolid in cerebrospinal fluid and serum in a patient with renal allograft tuberculosis and tuberculous meningoencephalitis.

Weijian Liu, Tian He, Hongjuan Qin, Peize Zhang

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Weijian Liu *1Department of Pulmonary Medicine & Tuberculosis, The Third People's Hospital of Shenzhen, National Clinical Research Center for Infectious Disease, Southern University of Science and Technology, Shenzhen, China.
Tian He *Department of Pharmacy, The Third People's Hospital of Shenzhen, National Clinical Research Center for Infectious Disease, Southern University of Science and Technology, Shenzhen, China.
Hongjuan Qin1Department of Pulmonary Medicine & Tuberculosis, The Third People's Hospital of Shenzhen, National Clinical Research Center for Infectious Disease, Southern University of Science and Technology, Shenzhen, China.
Peize Zhang1Department of Pulmonary Medicine & Tuberculosis, The Third People's Hospital of Shenzhen, National Clinical Research Center for Infectious Disease, Southern University of Science and Technology, Shenzhen, China. 82880246@qq.com.

Funding

National Key R&D Program of China 2023YFC2308300Shenzhen Clinical Research Center for Tuberculosis 20210617141509001Shenzhen Municipal Basic Research Program (Natural Science Foundation) JCYJ2-24-813101908012
6 · The paper itself

Abstract

Tuberculosis is a challenging and severe infection among solid organ transplant recipients. Contezolid, a new oxazolidinone antimicrobial, has exhibited potent activity against Mycobacterium tuberculosis with a safety profile superior to linezolid, which is constrained by adverse effects such as myelosuppression and peripheral neuropathy. We present here a case of a renal recipient who suffered from allograft tuberculosis and tuberculous meningitis. A contezolid-included regimen successfully treated him with no drug-related adverse effects and drug-drug interaction. Concentration of contezolid in serum and cerebrospinal fluid at various time points during treatment was monitored. Given the increased risk of TB in patients with organ transplantation and limited evidence of contezolid for tuberculous meningitis, further clinical studies are needed to investigate the appropriate dosage and application of contezolid in patients with the most devastating type of extra-pulmonary TB.Clinical trial number Not applicable.

Indexed as

Antitubercular AgentsKidney TransplantationMeningoencephalitisOxazolidinonesTuberculosis, MeningealAdultAllograftsHumansMaleMycobacterium tuberculosisAntitubercular AgentsOxazolidinonesContezolidDrug concentrationRenal allograftTuberculosisTuberculous meningoencephalitis

Identifiers

PMID41257614
PMCPMC12628617

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.