ArticleBMC geriatrics2025
Trajectory subgroups and influencing factors of nutrition-related risk in older NSCLC patients undergoing chemotherapy.
Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Association between prognostic nutritional index and prognosis in non-small cell lung cancer patients receiving PD-1/PD-L1 inhibitors: a meta-analysis.Frontiers in nutrition · 2026Pooled it
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5 authors.
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Abstract
backgroundMalnutrition in older non-small cell lung cancer (NSCLC) patients undergoing chemotherapy correlates with poor outcomes. While nutritional risk is dynamic, longitudinal trajectory patterns remain uncharacterized in this population.
objectivesThe present study aimed to explore the trajectory subgroups and influencing factors of nutrition-related risk over time among older adults with advanced NSCLC undergoing first-line chemotherapy.
designA retrospective longitudinal study.
methodsIn total, 353 patients aged > 60 years who were diagnosed with advanced NSCLC and received at least six cycles of chemotherapy at a single tertiary oncology center between January 2022 and June 2024 were enrolled in this study. Nutrition-related risk was assessed with Geriatric Nutritional Risk Index (GNRI). The trajectory subgroups of nutrition-related risk over time were analyzed using the latent class growth modeling (LCGM). An unordered multi-class logistic regression analysis was performed to find the influencing factors of different trajectories.
resultsThe average age of 353 patients was (68.2 ± 6.1) years, among which 272 (77.1%) were male. According to LCGM, the three categories of nutrition-related risk trajectories were identified, which were stable low risk group (n = 188, 53.3%), improving moderate risk group (n = 124, 35.1%), and persistent high to moderate risk group (n = 41, 11.6%). Unordered multi-class logistic regression analysis showed that age, smoking status, and hypertension were associated with the trajectory categories of nutrition-related risks.
conclusionsNutrition risk follows distinct trajectories during chemotherapy cycles, with 11.6% of older adults with NSCLC exhibiting sustained high vulnerability. Older age, smoking history, and hypertension are key predictors of this adverse trajectory. Assessment of these readily available and easily accessible clinical factors at treatment initiation may enable early identification of high-risk patients for targeted nutritional interventions.
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