ArticleBMC genomics2025
Integrating host-pathogen interaction genomics to boost wheat defense against septoria tritici blotch.
Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeSeptoria tritici blotch, caused by the ascomycete fungus Zymoseptoria tritici, is one of the major threats to global food security, significantly reducing wheat yields. Current control strategies rely heavily on fungicide applications, which can accelerate fungal adaptation and resistance, highlighting the urgent need for sustainable and durable disease management approaches.
methodsWe performed genome-wide association studies in wheat and fungal populations to identify novel marker-trait associations linked to virulence within the pathosystem. Additionally, we integrated marker information from both the host and pathogen to evaluate whether a dual-source approach could improve genomic prediction of wheat resistance and reveal specific host-pathogen interactions.
resultsWe identified five novel marker-trait associations potentially involved in pathogen recognition across six wheat chromosomes and two overlapping known QTL regions. On the pathogen side, we identified 29 candidate genes potentially associated with fungal virulence, including an effector-like protein. The integrated host-pathogen genomic selection models improved predictive accuracy by capturing both wheat genotype and pathogen variation, although host genetics explained most of the variation.
conclusionConventional single-genome models lacked power, underscoring the value of dual-genome approaches in complex pathosystems. These findings support modeling genotype-by-genotype interactions for breeding resistant cultivars while concurrently monitoring pathogen evolution.
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