ArticleBMC nephrology2025
Age-stratified mortality and associated risk factors in adults aged 65 years or older undergoing continuous kidney replacement therapy: a consecutive retrospective study.
Article in BMC nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAs life expectancy increases and more adults aged ≥ 65 years undergo continuous kidney replacement therapy (CKRT), grouping patients into narrower age groups-rather than treating those aged ≥ 65 years as a single category-can provide more precise insights into age-related mortality risks.
methodsThis consecutive, retrospective study examined adults aged ≥ 65 years who underwent CKRT for acute kidney injury (AKI) at a tertiary hospital between August 2017 and March 2024. Participants were stratified into three age groups; 65-74 years, 75-84 years, and ≥ 85 years. The outcomes included 48-hour, 7-day, and in-hospital mortality. Logistic regression analysis was used to identify the impact of stratified age on mortality and the factors associated with age-specific mortality in each group.
resultsAmong the 1017 eligible patients, 292 (28.7%) died within 48 h, 402 (39.5%) within 7 days, and 607 (59.7%) during hospitalization. Compared with patients aged 65-74 years, those aged 75-84 years and those aged ≥ 85 years did not have an increased risk of 48-h, 7-day, or in-hospital mortality after adjustment for clinical variables. In patients aged 75-84 years, a higher serum albumin level was independently associated with lower in-hospital mortality (adjusted odds ratio [aOR], 0.35; 95% confidence interval [CI], 0.16-0.70; P = 0.004). In patients aged ≥ 85 years, a higher body mass index was significantly associated with reduced 7-day mortality (aOR, 0.74; 95% CI, 0.52-0.95; P = 0.037) and in-hospital mortality (aOR, 0.65; 95% CI, 0.43-0.87; P = 0.014).
conclusionsIn adults aged ≥ 65 years undergoing CKRT, advanced age was not associated with increased risk of early or in-hospital mortality. Among those aged ≥ 75 years, indicators of baseline health and nutrition status were associated with mortality. Age alone should not preclude CKRT decision-making in patients aged ≥ 65 years with AKI.
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