ArticleBMC genomics2025
Emergence and regional evolution of Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae ST11 in China.
Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A dual-tier plasmid network model underpins the evolutionary success of pandemic Klebsiella pneumoniae ST11.Scientific reports · 2026Article
- Differential analysis of virulence and antibiotic resistance genes in ST11 CRKP and ST15 CRKP isolates from a tertiary hospital.Frontiers in microbiology · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
objectivesKlebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) sequence type (ST) 11 has emerged as a significant public health threat in China, yet its endemic population and evolutionary dynamics remain incompletely understood. To address this, we investigated the national distribution and local evolution of KPC-KP ST11 in China.
methodsOur analysis included 4,262 KPC-KP ST11 genomes, comprising 56 isolates from a Guangdong hospital and 4,206 publicly available genomes. The genomic analysis encompassed population structure, genome annotation, and evolutionary dynamics, and was conducted on all sequenced genomes.
resultsUsing a threshold of 10 core genome allelic differences, hierarchical clustering revealed 456 lineages, highlighting substantial regional-specific distribution. The majority of the genomes carried the bla
conclusionIn conclusion the evolutionary trajectories of KPC-KP ST11 offer valuable insights into localized persistence and intermittent dissemination, enhancing our understanding of its regional spread and adaptation.
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