Evidence map›Paper›PMID 41257492›Full record

ArticleBiomedical chromatography : BMC2025

A Validated UPLC-MS/MS Method for Monitoring Temozolomide and Perillyl Alcohol Metabolites in Biological Matrices: Insights From a Preclinical Pharmacokinetic Study.

Ariane Krause Padilha Lorenzett, Tatiane Patricia Babinski, Samila Horst Peczek, Ana Paula Tartari, Jeferson Ziebarth, Andressa Zago, Thais Carla Brussulo Pereira, Rubiana Mara Mainardes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical chromatography : BMC, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ariane Krause Padilha LorenzettLaboratory of Nanostructured Formulations, Universidade Estadual do Centro-Oeste, Guarapuava, Paraná, Brazil.
Tatiane Patricia BabinskiLaboratory of Nanostructured Formulations, Universidade Estadual do Centro-Oeste, Guarapuava, Paraná, Brazil.
Samila Horst PeczekLaboratory of Nanostructured Formulations, Universidade Estadual do Centro-Oeste, Guarapuava, Paraná, Brazil.
Ana Paula TartariLaboratory of Nanostructured Formulations, Universidade Estadual do Centro-Oeste, Guarapuava, Paraná, Brazil.
Jeferson ZiebarthLaboratory of Nanostructured Formulations, Universidade Estadual do Centro-Oeste, Guarapuava, Paraná, Brazil.
Andressa ZagoLaboratory of Nanostructured Formulations, Universidade Estadual do Centro-Oeste, Guarapuava, Paraná, Brazil.
Thais Carla Brussulo PereiraLaboratory of Nanostructured Formulations, Universidade Estadual do Centro-Oeste, Guarapuava, Paraná, Brazil.
Rubiana Mara MainardesLaboratory of Nanostructured Formulations, Universidade Estadual do Centro-Oeste, Guarapuava, Paraná, Brazil.ORCID https://orcid.org/0000-0002-4442-2075

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 429728/2018-2Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 009/2024
6 · The paper itself

Abstract

Glioblastoma multiforme (GBM) is among the most aggressive brain tumors, largely due to the restrictive blood-brain barrier (BBB) and limited drug bioavailability. Temozolomide (TMZ), an alkylating agent, and perillyl alcohol (POH), a monoterpene with antitumor properties, have shown promise in GBM therapy. This study developed and validated a UPLC-MS/MS method for the simultaneous quantification of TMZ, its active metabolite 5-aminoimidazole-4-carboxamide (AIC), and perillic acid (PA), the primary POH metabolite, in rat plasma and tissues. The method met FDA and EMA validation criteria, showing high selectivity, linearity (R

Indexed as

MonoterpenesTandem Mass SpectrometryTemozolomideAnimalsChromatography, High Pressure LiquidLimit of DetectionLinear ModelsLiquid Chromatography-Mass SpectrometryMaleRatsRats, Sprague-DawleyReproducibility of ResultsTissue DistributionMonoterpenesperillyl alcoholTemozolomidebioanalytical methodbioavailabilitybiodistributionglioblastoma

Identifiers

PMID41257492
PMCPMC12628652

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.