Evidence map›Paper›PMID 41257441›Full record

ArticleJournal of pediatric gastroenterology and nutrition2026

Characterization of pediatric eosinophilic gastrointestinal disorders beyond eosinophilic esophagitis in a nationwide cohort.

Sara Renzo, Luca Scarallo, Selene Del Vespa, Giulia Angelino, Matteo Bramuzzo, Enrico Felici, Flavio Labriola, Francesca Laganà, Lorenzo Norsa, Salvatore Oliva and 7 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatric gastroenterology and nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Sara RenzoGastroenterology and Nutrition Unit, Meyer Children's Hospital IRCCS, Florence, Italy.ORCID https://orcid.org/0009-0007-6094-7983
Luca ScaralloGastroenterology and Nutrition Unit, Meyer Children's Hospital IRCCS, Florence, Italy.
Selene Del VespaGastroenterology and Nutrition Unit, Meyer Children's Hospital IRCCS, Florence, Italy.
Giulia AngelinoGastroenterology and Nutrition Unit, Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy.
Matteo BramuzzoGastroenterology, Digestive Endoscopy and Nutrition Unit, Institute for Maternal and Child Health-IRCCS "Burlo Garofolo,", Trieste, Italy.
Enrico FeliciPediatric and Pediatric Emergency Unit, "Umberto Bosio" Center for Digestive Diseases, The Children Hospital, AO SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Flavio LabriolaPediatric Gastroenterology Unit, Maggiore Hospital, Bologna, Italy.
Francesca LaganàPediatric Gastroenterology and Cystic Fibrosis Unit, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Messina, Italy.
Lorenzo NorsaPediatric Department, Children's Hospital Vittore Buzzi, University of Milan, Milan, Italy.
Salvatore OlivaMaternal and Child Health Department, Pediatric Gastroenterology and Liver Unit, Sapienza - University of Rome, Rome, Italy.
Marisa PiccirilloSapienza University of Rome, NESMOS Department, Pediatric Unit, Sant'Andrea University Hospital, Rome, Italy.
Elena PozziPediatric Department, Children's Hospital Vittore Buzzi, University of Milan, Milan, Italy.
Francesca ReaGastroenterology and Nutrition Unit, Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy.
Giusy RussoMaternal and Child Health Department, Pediatric Gastroenterology and Liver Unit, Sapienza - University of Rome, Rome, Italy.
Francesco ValituttiPediatric Section, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Giovanna ZuinPediatric Department Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Paolo LionettiGastroenterology and Nutrition Unit, Meyer Children's Hospital IRCCS, Florence, Italy.

Funding

None
6 · The paper itself

Abstract

objectivesNonesophageal eosinophilic gastrointestinal disorders (non-EoE EGIDs) are rare, underrecognized inflammatory diseases of the gastrointestinal (GI) tract, especially in children. Their clinical heterogeneity and lack of specific biomarkers contribute to diagnostic delays and therapeutic challenges.

methodsThis retrospective multicenter study included pediatric patients (<18 years) diagnosed with non-EoE EGIDs across 12 Italian centers affiliated with the Italian Society of Pediatric Gastroenterology Hepatology and Nutrition (SIGENP). The data were retrospectively collected from January 2012 to December 2022. Diagnosis was based on ESPGHAN histological criteria. Clinical, laboratory, endoscopic, and histological data were collected at baseline and during follow-up. Treatment modalities and outcomes were analyzed.

resultsA total of 86 patients (71% male; median age 10.5 years) were included. The stomach was the most commonly involved site (45.4%), followed by the small bowel (40.7%) and colon (24.4%). Multiple segment involvement occurred in 45.4% of cases. Abdominal pain (64.9%) and diarrhea (38.2%) were the most common symptoms, with diarrhea significantly associated with colonic involvement. Laboratory findings showed peripheral eosinophilia in 50% of patients and hypoalbuminemia in those with multisegment involvement. Very early-onset EGIDs (>1 and <2 years) were associated with features such as predominant colonic involvement and anemia. Treatment responses varied: 50% achieved clinical remission after first-line therapy (proton pump inhibitors, topical/systemic steroids, or elimination diets). Among 61/86 patients who underwent endoscopic follow-up, 49.2% achieved macroscopic remission and 40.9% histological remission.

conclusionsPediatric non-EoE EGIDs present with heterogeneous symptoms and variable tract involvement. Younger children show distinct phenotypes. Laboratory findings are nonspecific and have limited diagnostic utility. Treatment remains challenging, with suboptimal response rates. These findings underscore the need for prospective studies.

Indexed as

EnteritisEosinophiliaGastritisGastrointestinal DiseasesAbdominal PainAdolescentChildChild, PreschoolEosinophilic EsophagitisFemaleHumansInfantItalyMaleRetrospective Studiesbudesonideeosinophiliavery early onset‐EGIDs

Identifiers

PMID41257441
PMCPMC12864182

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.