SynthesisBiopsychosocial science and medicine
Perceived Discrimination and Immunological Aging: A Systematic Review of Cellular and Molecular Markers.
Synthesis in Biopsychosocial science and medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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Authors and funding
9 authors.
Funding
Abstract
objectivePerceived discrimination is a chronic social stressor that increases the risk of disease. While prior research has linked discrimination to adverse biological health outcomes, the cellular and molecular mechanisms underlying these associations remain understudied.
methodsWe conducted a systematic review and identified 32 empirical studies that met the inclusion criteria examining the relationship between self-reported discrimination experiences and markers of immunological aging, focusing on telomere length, gene expression profiles, and immune cell composition.
resultsFindings consistently showed discrimination to be associated with accelerated telomere shortening; altered transcriptional activity, particularly within proinflammatory and antiviral pathways aligned with the Conserved Transcriptional Response to Adversity; and shifts in immune cell populations indicative of immune aging and heightened inflammatory activity. Despite this growing evidence, the dominance of cross-sectional designs, limited racial/ethnic diversity in study populations, and narrow focus on select immune markers restrict generalizability and mechanistic clarity.
conclusionWe emphasize the need for longitudinal research, broader immune phenotyping, and rigorous modeling of behavioral and physiological mediators to elucidate how discrimination drives chronic immune dysregulation. Advancing this field is essential for understanding the biopsychosocial pathways linking discrimination to disease.
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