ArticleWorld journal of gastroenterology2025
Real-world performance of transient elastography in assessing advanced fibrosis in Chinese patients with primary biliary cholangitis.
Article in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Dual cut-offs and beyond: Expanding the role of transient elastography in primary biliary cholangitis.World journal of gastroenterology · 2026Article
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5 authors.
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Abstract
backgroundThere is insufficient evidence on the evaluation of liver fibrosis in Asian individuals with primary biliary cholangitis (PBC) using vibration-controlled transient elastography (VCTE).
aimTo assess advanced fibrosis (AF) using liver stiffness measurement (LSM) in Chinese patients with PBC.
methodsIn total, 277 Chinese patients diagnosed with PBC who underwent liver biopsy and VCTE were retrospectively included and categorized into the derivation and validation cohorts. The areas under the receiver operating characteristic curves (AUROCs) with 95% confidence intervals (CIs) were used to estimate the diagnostic accuracy of LSM for AF (Ludwig stage ≥ III). Multivariable analysis was performed using logistic regression.
resultsIn the derivation cohort, VCTE accurately detected patients with AF, achieving an AUROC of 0.93 (95%CI: 0.88-0.96). AF was independently predicted by LSM according to multivariable analysis. AF can be excluded and confirmed using LSM cutoffs of ≤ 10.0 and > 14.5 kPa, respectively, with a sensitivity of 0.91, negative predictive value of 0.93, specificity of 0.96, positive predictive value of 0.92, and an error rate of 7.5%. The accuracy of these values was validated in an independent cohort, achieving an AUROC of 0.97 (95%CI: 0.90-0.99) for AF with a sensitivity of 0.89, negative predictive value of 0.88, specificity of 0.95, positive predictive value of 0.94, and error rate of 9.0%. Compared with serum fibrosis markers, the AUROC of LSM was significantly higher in both the derivation and validation cohorts.
conclusionVCTE has a high accuracy for assessing AF in Chinese patients with PBC in a real-world setting.
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