ArticleFrontiers in cardiovascular medicine2025
Myocardial work in Chagas disease: comparative analysis with conventional parameters in different cardiac clinical stages.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Inflammaging and cytokine-driven cardiovascular senescence in age-related myocardial infarction: mechanisms, biomarkers, and precision immunotherapy strategies.Biogerontology · 2026Review
- Cardiac imaging in Chagas cardiomyopathy for phenotypic characterisation and risk stratification.Heart failure reviews · 2026Review
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Authors and funding
8 authors.
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Abstract
Chagas disease (CD) is a neglected chronic infectious disease and represents an important cause of morbidity and mortality in endemic areas of Latin America. Chronic Chagas cardiomyopathy (CCC) is the most severe manifestation of the disease and the leading cause of death in these patients. Myocardial deformation, measured by speckle-tracking echocardiography (STE), has been proven to detect subclinical disease and has prognostic value in CCC, but it is load dependent. We aimed to characterize myocardial work (MW) as new, less load-dependent, echocardiographic variables in patients with different clinical stages of CCC and to assess its correlation with left ventricular (LV) ejection fraction (EF) and accuracy to detect LV dysfunction, compared with routinely used parameters. Fifty consecutive patients with CD were included. Clinical assessment, NT-proBNP, and a comprehensive 2D echocardiogram were performed. Patients were divided into four groups, depending on disease stages: Stage A-indeterminate form (
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