ArticleFrontiers in cardiovascular medicine2025
Pre-arrest oral anticoagulants' impact on cardiac arrest mortality: MIMIC-IV cohort retrospect.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The impact of oral anticoagulant use prior to cardiac arrest (CA) on short-term and long-term all-cause mortality remains largely unknown. This study aimed to explore the association between pre-arrest oral anticoagulant use and both immediate and extended survival outcomes following CA. Methods: We identified 1,203 adult CA patients from the Medical Information Mart for Intensive Care IV (MIMIC-IV V3.1) database, grouped by prior oral anticoagulant use. Propensity score matching (PSM) was conducted to minimize confounding effects. Adjusted Cox proportional hazards models were applied to account for pre-hospital and hospitalization factors. Results: Patients in the anticoagulant group demonstrated a significantly higher 28-day survival rate [hazard ratio (HR) 0.28; 95% confidence interval (CI) 0.22-0.37; Conclusion: Pre-arrest oral anticoagulant use may be associated with improved survival outcomes in CA patients.
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