ArticleJournal of pain research2025
Evaluating the Content Validity of the Modified Neuropathy Total Symptom Score-6 Self-Administered (mNTSS-6-SA) in a Painful Diabetic Peripheral Neuropathy Population.
Article in Journal of pain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07708233 (A 12-Week Double-blind Randomized Controlled Study; Comparing the Efficacy of Benfotiamine and Vitamin b1-6-12 in Alleviating Numbness, Sensory Neuropathy Symptoms and Pain in Patients With Diabetic Peripheral Neuropathy), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A 12-Week Double-blind Randomized Controlled Study; Comparing the Efficacy of Benfotiamine and Vitamin b1-6-12 in Alleviating Numbness, Sensory Neuropathy Symptoms and Pain in Patients With Diabetic Peripheral Neuropathy
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: People with diabetes often develop painful diabetic peripheral neuropathy (pDPN). Symptoms of pDPN vary and often lead to impairments in basic daily activities and negative impacts on quality of life. The Neuropathy Total Symptom Score-6 (NTSS-6) assesses the frequency and intensity of six neuropathic sensory symptoms. Validity of the NTSS-6 for neuropathic populations has been evaluated for a 24-hour clinician-reported version and 4-week self-administered (SA) version. The aim of this study was to evaluate the content validity of the Neuropathy Total Symptom Score-6 self-administered (NTSS-6-SA) modified for use with a 7-day recall period in a sample of people with pDPN. Methods: This was an observational qualitative study consisting of concept elicitation and cognitive debriefing interviews. The study included 25 US-based, English-speaking adults who had a physician-confirmed diagnosis of DPN and who self-reported moderate-to-severe pain in their feet or legs. Participants were asked to describe their experiences with pDPN and to review the NTSS-6-SA with a 7-day recall period. Based on findings from the first 13 interviews (Wave 1), the NTSS-6-SA was modified to address minor comprehension problems and incorporate patient feedback. The modified NTSS-6-SA (mNTSS-6-SA) was then reviewed in 11 interviews (Wave 2). Results: The measure was interpreted as intended, well-understood, and included content relevant to the experiences that study participants found important. Conclusion: The evidence from this study supported the content validity of the mNTSS-6-SA for the pDPN population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.