ArticleResearch and practice in thrombosis and haemostasis2025
Comparative
Article in Research and practice in thrombosis and haemostasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
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Abstract
Background: Mim8 is a next-generation activated factor (F)VIII-mimetic, bispecific antibody, currently in clinical development for the prophylactic treatment of hemophilia A. To evaluate the Objectives: To compare the pharmacodynamic results from FRONTIER1 and FRONTIER2 by evaluating Mim8 Methods: TG was assessed Results: Within the tested Mim8 concentration range, a constant TG response ratio was observed between the 2 triggers. TF-triggered peak thrombin levels were approximately 3 to 4 times lower than those triggered by FXIa. Both triggers exhibited similar endogenous thrombin potential responses, although FXIa showed slightly higher values. These differences were consistent in both Conclusion: While both assays are considered relevant for assessing Mim8 pharmacodynamic response, systematic and consistent differences between TGAs triggered by FXIa and TF were observed, indicating different kinetics in the intrinsic and extrinsic pathways.
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