Evidence map›Paper›PMID 41257193›Full record

ArticleChemical science2026

Yeast [FeFe]-hydrogenase-like protein Nar1 binds a [2Fe-2S] cluster.

Joseph J Braymer, Lukas Knauer, Jason C Crack, Jonathan Oltmanns, Melanie Heghmanns, Jéssica C Soares, Nick E Le Brun, Volker Schünemann, Müge Kasanmascheff

Abstract read
In one paragraph

Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joseph J BraymerFachbereich Medizin, Institut für Zytobiologie und Zytopathologie & Zentrum für Synthetische Mikrobiologie (Synmikro), Philipps-Universität Marburg Karl-von-Frisch-Str. 14 35032 Marburg Germany.ORCID https://orcid.org/0000-0003-1404-4066
Lukas KnauerFachbereich Physik, Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau Erwin-Schrödinger-Str. 46 D-67663 Kaiserslautern Germany.
Jason C CrackCentre for Molecular and Structural Biochemistry, School of Chemistry, Pharmacy, and Pharmacology, University of East Anglia Norwich Research Park Norwich NR4 7TJ UK.
Jonathan OltmannsFachbereich Physik, Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau Erwin-Schrödinger-Str. 46 D-67663 Kaiserslautern Germany.
Melanie HeghmannsFakultät für Chemie und Chemische Biologie, Technische Universität Dortmund Otto-Hahn-Straße 6 44227 Dortmund Germany.
Jéssica C SoaresFachbereich Chemie, Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau Erwin-Schrödinger-Str. 52 D-67663 Kaiserslautern Germany.
Nick E Le BrunCentre for Molecular and Structural Biochemistry, School of Chemistry, Pharmacy, and Pharmacology, University of East Anglia Norwich Research Park Norwich NR4 7TJ UK.ORCID https://orcid.org/0000-0001-9780-4061
Volker SchünemannFachbereich Physik, Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau Erwin-Schrödinger-Str. 46 D-67663 Kaiserslautern Germany.ORCID https://orcid.org/0000-0002-3162-1032
Müge KasanmascheffFakultät für Chemie und Chemische Biologie, Technische Universität Dortmund Otto-Hahn-Straße 6 44227 Dortmund Germany.ORCID https://orcid.org/0000-0002-8964-8924

Funding

Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
NIGMS NIH HHS P41 GM103311
6 · The paper itself

Abstract

Nar1 is an essential eukaryotic protein proposed to function as an iron-sulphur (Fe/S) cluster trafficking factor in the cytosolic iron-sulphur protein assembly (CIA) machinery. However, such a role has remained unclear due to difficulties in purifying adequate amounts of cofactor-bound protein. The [FeFe]-hydrogenase-like protein has two conserved binding sites for [4Fe-4S] clusters but does not show hydrogenase activity

Identifiers

PMID41257193
PMCPMC12621388

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.