ArticleERJ open research2025
Neutrophil extracellular traps are increased in the airways of obese asthmatic patients.
Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Metabolic Reprogramming and ILC2 Plasticity in Obesity-related Asthma.Clinical reviews in allergy & immunology · 2026Review
- Neutrophil extracellular traps in asthma and chronic obstructive pulmonary disease: pathogenic roles, and therapeutic opportunities.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Asthma in people who are obese is often more difficult to manage and is associated with worse lung function and increased symptoms compared with asthma in non-obese people. This may involve airway neutrophilia, as neutrophilic airway inflammation is associated with more severe, steroid-resistant asthma. Neutrophil extracellular traps (NETs) are released from activated neutrophils and the level of NETs in airways disease has been associated with poor lung function. The aim of this study was to examine the presence of airway NETs in obese people with asthma. Methods: Sputum samples from obese (n=63) and non-obese (n=61) subjects with asthma were analysed for NET content by measuring extracellular DNA (eDNA) by PicoGreen and DNA-elastase complexes by ELISA. Lung function was assessed by spirometry and asthma control was assessed by the Asthma Control Questionnaire-6 (ACQ6). Results: DNA-elastase complexes were significantly increased in obese people with asthma (64.3 µg·mL Conclusion: NETs are increased in obese individuals with asthma and are associated with body mass index. Sputum eDNA is associated with poorer lung function and is also associated with sputum NETs. Hence, NETs may be a potential therapeutic target for obese asthmatic patients.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.