ArticleCureus2025
Can Fractional Flow Reserve-Computed Tomography (FFR-CT) Overestimate the Severity of Coronary Stenoses in the Presence of High Calcium Burden?
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Non-invasive diagnostic methods such as coronary artery calcium (CAC) scoring, computed tomography angiography (CTA), and fractional flow reserve-computed tomography (FFR-CT) are useful to predict the presence of coronary artery stenosis, but may provide false positive results as well. This case describes a man in his mid-60s with significant cardiac history who presented to the emergency department with chest pain. Extensive workup included CTA, which demonstrated severe coronary artery calcification and abnormal FFR-CT suggestive of severe three-vessel disease. Urgent invasive coronary angiography was performed due to his high likelihood of flow-limiting stenosis; however, it revealed only mild-to-moderate non-obstructive (<50%) stenoses. This report highlights the potential of CAC, CTA, and FFR-CT to overestimate the severity of coronary artery disease.
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