ArticleCureus2025
Severe Primary Hypothyroidism in a Child Presenting as a Pituitary Tumour: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
Primary hypothyroidism in children often manifests as short stature, and if untreated, it can result in pituitary hyperplasia due to chronic thyrotropin-releasing hormone (TRH) drive resulting from the loss of negative feedback by low circulating thyroid hormones, potentially leading to unnecessary surgery. We report the case of a nine-year-old patient with a persistent headache with a suspected diagnosis of a pituitary mass. Blood tests revealed severe hypothyroidism (extremely elevated thyroid-stimulating hormone (TSH) and suppressed free thyroxine (T4). The initial MRI led to a misdiagnosis of pituitary adenoma. Reversible pituitary hyperplasia completely regressed following levothyroxine therapy. This case highlights the relevance of considering hypothyroidism when evaluating pituitary masses. Thyroid function should always be assessed before considering pituitary surgery in children.
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